Last Set 3 Flashcards
Loss of pain and temp on C/L body Loss of pain and temp on ipsl face Hoarseness Difficulty swallowing Loss of gag reflex Vertigo Nystagmus N/V
Lateral Medullary syndrome (Wallenberg)
PICA
Dysphagia Dysphonia Dysarthria C/L spastic hemiparesis Ipsl ptosis Pupillary dilation Lateral strabismus (down and out)
Weber syndrome
Anterior midbrain infarction resulting from occlusion of paramedian branches of the posterior cerebral artery
Oculomotor nerve
Cerebral peduncle lesion
Carotid sheath contains (3)
Internal jugular v.
Common carotid A.
Vagus n.
Magnetic gait
Normal pressure hydrocephalus
Wet wacky wobbly
Urinary incontinence
Dementia
Gait disturbances
Jaw muscle pain when chewing
Giant cell arteritis
Temporal arteritis
Headache + Extraocular muscular palsies
Cavernous sinus thrombosis
Rapidly progressive primary brain tumor Irregular necrotic center Surrounded by edema GFAP stain Pseudopalasating pattern "snake like"
Glioblastoma
Slow growing primary brain tumor
“Whorled”
Surface of brain
Psammoma bodies
- originates
- risk
Meningioma
Arachnoid cells
Risk
- Radiation
- Neurofibromatous type 2
Slow growing brain tumor
Frontal lobe
Perinuclear cytoplasmic clearing
Oligodendroglioma
Posterior fossa brain tumor
GFAP
Rosenthal fibers
Pilocytic astrocytoma
Rosenthal fibers: eosinophilic corkscrew fibers
Rathke’s pouch
Compresses optic chiasm
Supratentorial tumor of childhood
Craniopharyngioma
Malignant brain tumor
Cerebellar
Compress 4th ventricle
Homer-wright rosettes
Medulloblastoma
Cells circle around tangle of fibers
Compress 4th ventricle
Peri-vascular pseudo-rosettes
Ependymona
Circular arrangement of cell around vessel
Eosinophilic corkscrew fibers
Rosenthal fibers
Pilocytic astrocytoma
Uvela deviates to right, damage to what 2 things
Left vagus n.
Left nucleus ambiguus
alpha 1
alpha 2
Beta 1
Beta 2
Alpha 1: vascular smooth m. contraction
- increase resistance and BP
- bladder sphincter contraction
Alpha 2: Inhibit NE release
Beta 1: Heart
- Tachycardia
- increase contractility
- release renin
Beta 2: Lungs
- Vasodilation
- bronchodilation
- insulin release
- decrease uterine tone
Structures in cavernous sinus
Oculomotor Trochlear n. Abducens Opthalmic div V1 Maxillary div V2
Internal carotid A.
Aortic arches
Most likely to be test on 3rd and 4th
1st
- Part of maxillary A.
2nd
- stapedial A.
- hyoid A.
3rd
- common carotid a.
- proximal part of internal carotid A.
4th
- Left: arch of adult aorta
- Right: Proxiaml part of right subclavian a.
6th
- proximal part of pulmonary A.
- Ductus arteriosus
Pregestational diabetes possible heart defect
Transposition of great vessels
Mean arterial pressure (P) =
MAP = Cardiac output (Q) x Peripheral resistance (R)
P= QxR
MAP= 2/3 diastolic pressure + 1/3 systolic pressure
Liver disease does what to starling forces
Decreases plasma colloid osmotic pressure
Affect on starling forces
- HF
- Liver failure
- Oliguric renal failure
- Infections
- Nephrotic syndrome
- Lymphatic blockage
- Burns
- Diuretic administration
- IV infusion of albumin
- Venous insufficiency
- HF= Increase Pc
- Liver failure= Decrease TTc
- Oliguric renal failure= Increase Pc
- Infections= Increase Kf
- Nephrotic syndrome= Decrease TTc
- Lymphatic blockage= Increase TTi
- Burns= Increase Kf
- Diuretic administration= Decrease Pc
- IV infusion of albumin= Increase TTc
- Venous insufficiency= Increase Pc
Inspiration makes what murmur louder
Tricuspid
What murmur is louder with expiration
Mitral
MOA of N-acetylcysteine for acetaminophen overdose
Regenerates glutathione
9;22
cell looks like
CML
Blood smear shows leukocytosis with many immature myeloid cells (horseshoe nucleus)
12;21
B cell- ALL
Anemia
Thrombocytopenia
Lymphoblasts
Basaloid cells with peripheral palisading nuclei
Basal cell carcinoma
Slow growing papules, ulceration or rolled border
Allelic heterogeneity
Multiple genes same phenotype
Genetic mutations chromosome 7
Cystic fibrosis
Ehlers Danlos
Osteogenesis imperfecta
Genetic mutations chromosome 16
Polycystic kidney disease
Tuberous sclerosis
Increase in branched chain alpha-keto acid
What can also be deficent
Maple syrup urine disease
Alpha ketoacid dehydrogenase require thaimine pyrophosphate (Vit B1) as coenzyme
Glucose 6 phosphatase deficiency
Von Gierke disease
Glycogen phosphorylase deficiency
McArdle
Chromogranin
Carcinoid tumor
Secretes serotonin
Diabetes medications
- Acarbose
- Canagliflozin
- Glyburide
- Pioglitazone
- Repaglinide
Acarbose
-intestinal brush border alpha glucosidase inhibitor decreases postprandial hyperglycemia by reducing GI absorption of glucose
Canagliflozin
- sodium glucose cotransporter 2 inhibitors, act on kidney to decrease reabsorption of filtered glucose
Glyburide (sulfonylureas) and Meglitinides (repaglinide)
- bind to and close ATP sensitive K channels in pancreatic beta membrane
- depolarize and open L type Ca channel
- Increase Ca influx, insulin release
Pioglitazone (Thiazolidinediones) peroxisome proliferator-activated receptor gamma (PPAR-y)
- decrease insulin resistance
- expression glut 4
- adiponectin
Celiac disease location
Distal duodenum
Proximal jejunum
Cystic fibrosis type of mutation
Frame shift
Stimulates neutrophil migration to sites of inflammation
Leukotriene B4
Hyperlipoproteinemias types
Type I (AR)
- Familial chylomicroenemia
- Defect: Lipoprotein lipase
- Defect: ApoC-2 production
- Elevated chylomicrons
- Acute pancreatitits*, Lipemia retinalis, eruptive xanthomas
Type IIA - Familial hypercholesterolemia - Defect: LDL receptor - Defect: ApoB-100 - Elevated LDL* (Impaired LDL particle uptake by hepatocytes) -Premature atherosclerosis* - Tendon xanthomas, xanthelasmas (yellow deposit around eyes)
Type III
- Familial dysbetalipoproteinemia
- Defect ApoE
- Elevated: chylomicron & VLDL remnants
- Premature atherosclerosis*
- Tuboeruptive and palmar xanthomas
Type IV
- Familial hypertriglyceridemia
- Defect Polygenic
- Elevated VLDL
- Associated with coronary disease, pancreatitis and diabets
Measuring pressure in pulmonary artery is also measuring pressure where?
Left atrial pressure
Ammonium and bicarbonate generated from AA
Urea and ornithine produced from
pyruvate produced from AA
oxaloacetate produced from AA
glutamine
arginine
Alanine
aspartate
Intellectual disability
Hx of seizures
Abnormal pallor of substantia nigra, locus ceruleus and vagal nucleus dorsalia
Phenylalanine hydroxylase deficiency
PKU
Cant convert phenylalaine to tyrosine
Acute compartment syndrome (ACS) affects what in the leg
Foot extensors
Anterior tibial A.
Deep peroneal (Fibular) nerve
Pleiotrophy
One mutation multiple things wrong w/ person
Takes place in cytosol vs mitochondria
Cytosol
- Glycolysis
- FA synthesis
- Pentose phosphate pathway
Mitochondria
- beta oxidation of fatty acids
- citric acid cycle
carboxylation of pyruvate (gluconeogenesis)
Interferon alpha and beta do what
halt protein synthesis
Only works on dsDNA
Anemia
Hypercoagulability
Pancytopenia
Paroxysmal nocturnal hemoglobinuria (PNH)
Mutation PIGA
Deficiency: glycosylphosphatidylinositol (GPI) anchor
Deficiency: CD55 CD59
Tx Manic depression
Valproic acid
Lithium
Carbamazepine
Replicative process
1) DS dna –> DS dna template –> ds DNA progeny
2) DS dna -> +RNA template -> partially ds-DNA
3) ssDNA –> ds DNA template –> ss DNA progeny
4) ss +RNA –> ds DNA template –> ss +RNA progeny
5) ss +RNA –> - RNA template –> ss + RNA progeny
6) ss -RNA –> +RNA template –> ss -RNA progeny
1) Adenovius, herpesvirus, poxvirus
2) Hepatitis virus
3) Parvovirus B19
4) Retroviruses (HIV)
5) poliovirus
6) Influenza virua, measles virus, rabies virus
Polyostotic Fibrous dysplasia
associated with
Bone replaced by collagen and fibroblast
Assoc with McCune Albright syn
- Precocious puberty
- Cafe au lait
- Fibrous dysplasia bone
Fibromyalgia
Excess tenderness at 11 of 18 sites
Fatigue
Tx. Pregabalin, milnacipran
cellulitis tx
- description
- organisms
- MRSA
- non-MRSA
Painful tender to touch Rapidly spreads
S. Aureua
S. Pyogenes
Non-MRSA( no abscess)
- oral dicloxacillin, cephalexin
MRSA:
- oral trimethoprim/sulfamethoxazole
- clindamycin
Precocious puberty
Cafe au lait spots
Fibrous dysplasia bone
McCune albright syndrome
Necrotizing fasciitis organism
Tx
Strep. pyogenes
Anaerobic bacteria
Tx: Debridement
IV carbapenem
clindamycin
Painful flaccid blister
biopsy shows
Ab against
test
unique feature
Pemphigus vulgaris
acantholysis
Ab desmosomes
Positive Nikolsky sign
oral lesions
Tight raised blister
biopsy shows
Ab against
test
unique feature
[Bullous pemphigoid- Tight raised blister]
- Ab to hemidesmosomes
- Eosinophils within blister
- Negative nikolsky
- no oral lesion
Blister IgA in tips of dermal papillae
Dermatitis herpetiformis
assoc w/ celiac
Pruritic, purple, polygonal papules and plaques
- microscopically see
- assoc with
Lichen planus
Sawtooth pattern at dermal-epidermal junction
Hepatitis C
Erythema nodosum assoc with
Painful raised lesions on shins
Sarcoidosis, histoplasmosis, Tb, leprsy
Erythema multiforme
Target lesions
Ligaments of ovaries/ uterus with no vessels
Round ligament of uterus
- gubernaculum
- uterus thorugh inguinal canal to labia majorum
Ovarian ligament
- ovary to uterus
- gubernaculum
Indirect inguinal hernia
Direct inguinal hernia
Indirect inguinal hernia
- Most common
- Congenital due to failure of closure of processus vaginalis
- Protrude through deep inguinal ring, lateral to inferior epigastric vessels and pass through inguinal canal
Direct inguinal hernia
- Weakening of abdominal wall in Hesselbach’s triangle
- Increase pressure heavy lifting
- Directly through abdominal wall medial to inferior epigastric vessel, exit out superficial inguinal ring
Genital homologs
1) Glans penis
2) Corpus spongiosum and corpus cavernosum
3) Bulbourethral (Cowper) glas
4) Prostate gland
5) Ventral shaft of penis
6) Scrotum
1) Glans penis= glans clitoris
2) Corpus spongiosum and corpus cavernosum= vestibular bulbs
3) Bulbourethral (Cowper) glands= Greater vestibular (Bartholin) glands
4) Prostate gland= Urethral and paraurethral (skene) glands
5) Ventral shaft of penis= Labia minora
6) Scrotum= Labia majora
Amenorrhea
Loss of smell
Kallman syndrome
Defect of X linked KAL chain
Decrease GnRH –> Low LH and FSH
Prostatitis or Epididimitis
- Organism
- Tx
<35: Gonorrhea, Chlamydia
> 35: E coli, klebsiella, serratia, enterobacter, proteus
GC/Chlamydia: Ceftrixone (IM) then doxycycline
Ecoli: Fluoroquinolone
Tx: Fluoroquinolone (levofloxacin), TMP-SMX
Byproducts of MAO and COMT enzymatic activity of dopamine, NE, Epinephrine
Dopamine –> homovanillic acid (HVA)
NE –> Vanillylmandelic acid (VMA)
Epi –> Metanephrine
Smooth white plaques on vulva
Parchment paper
Fusion of labia majora and minora
- due to
- tx
- risk of
Lichen sclerosus
Thinning of epidermis
Corticosteroids
SCC of vulva
Koilocytosis
- looks like
- assoc with (3)
Enlarged nuclei and perinuclear halo
Fried egg
Seminoma
Dysgerminioma
HPV
Rosettes of tumor cells surrounding eosinophilic spaces
Call- Exner body
Granulosa cell tumors
yellow
produce estrogen
Meigs syndrome
Ovarian tumor
Ascites
Pleural effusion
Bloody brown vaginal discharge
- arises from
- metastasizes to
Choriocarcinoma
Complete mole, miscarriage, normal pregnancy, ectopic pregnancy
Lung
Trisomy 21 lab values
Trisomy 18
Trisomy 13
Decrease AFP
Decrease estriol
Increase hCG
Increase inhibin
Decrease AFP
Decrease estriol
Decrease hCG
Decrease hCG, PAPP-A
Kleinfelter labs
Testicular atrophy
Decrease testosterone
Decrease inhibin
Increase FSH
High-pitched crying and newing
also seen (4)
Mutation
Cri-du-chat syndrome
Microcephaly
Severe intellectual disability
Epicanthal folds
Cardiac abnormalities
5p deletion
William syndrome
- characteristics (5)
- mutation
Elfin facies Intellectual disability Hypercalcemia (hypersensitivity to Vit D) Good verbal skills Friendly w/ strangers
Microdeletion of long arm of chr 7
Bilateral acoustic neuroma
Hearing loss
Tinnitus
mutation
NF2
Chr 22 AD
Cafe au lait spots
Neural tumor
Lisch nodules (pigment hamartoma in eye)
Scoliosis
mutation
NF I
AD mutation chr 17
Facial lesions Hypopigmented ash leaf spots Cortical and retinal hamartomas seizures intellectual diability
Tuberous sclerosis
Mutation of hamartin or tuberin gene
AD disease fits
1) Associated with mitral valve prolapse, liver disease, berry aneurysms
2) Neural tumors and pigmented iris hamartomas
3) Very strong association with colon cancer
4) MI before age 20
5) Hemangioblastomas of retina/ cerebellum/ medulla
6) Increased MCHC, hemolytic anemia
7) Bilateral acoustic neuromas
8) Facial lesions, seizure disorder, cancer risk
9) Caudate atrophy, dementia
10) Cystic medial necrosis of aorta
11) Defect of FGF receptor 3
12) Assoc w/ floppy mitral valve, dissecting aortic aneurysm
1) ADPKD
2) NF1
3) Familal adenomatous polyposis
4) Familial hypercholestrolemia
5) VHL
6) Hereditary spherocytosis
7) NF2
8) Tuberous sclerosis
9) Huntington’s dis
10) Marfan syn
11) Achondroplasia
12) Marfan syndrome
Painless papules on lower abdomen
peripheral neuropathy
glomerulopathy (renal failure)
Fabry disease
Deficient: alpha- galactosidase
Accumulation: ceramide trihexoside; globotriaosylceramide
Hepatosplenomegaly Cherry red spot Painful bony lesions Anemia Fatigue thrombocytopenia
-Microscopically
Gaucher disease
Deficient: glucocerebrosidase
Accumulation: Glucocerebroside
Prominent blue cytoplasmic fibrils (crumpled tissue paper)
Hepatosplenomegaly Cherry red spot Thrombocytopenia Ataxia Dysarthria Dysphagia Gradual worsening of intellectual fxn
- Mircoscopically
Niemann-Pick disease
Deficient: Sphingomyelinase
Accumulation: sphingomyein
Foam cells
Irritability
Regression of motor skills
Macrocepahly
Cherry red spot
Tay-Sachs
Deficient: hexosaminidase A
Accumulation: GM2 ganglioside