last minute 'omas

Question 1

bone pain (usually in the back or chest) with anemia

Answer 1

multiple myeloma

Question 2

pathologic fractures

Answer 2

multiple myeloma

Question 3

Bence Jones proteinuria

Answer 3

Multiple myeloma

Question 4

High calcium, LDH and uric acid

Answer 4

multiple myeloma

Question 5

osteolytic lesions

Answer 5

multiple myeloma

Question 6

3 criteria to dx mm

Answer 6

presence of monoclonal protein
presence of plasma b cells in marrow
end organ damage such as (increased Ca2+, lytic bone lesions, anemia, or renal failure)

Question 7

Bortezomib

Answer 7

multiple myeloma

Question 8

in multiple myeloma you can also give what which can cause ONJ

Answer 8

bisphosphonates

Question 9

high tumor burden

Answer 9

lymphoma

Question 10

itching

Answer 10

lymphoma

Question 11

to diagnose lymphoma you need to…

Answer 11

biopsy the node and phenotype it.

Question 12

its either aggressive with systemic b syptoms or indolent with slow growing LAN, hepatosplenomegaly, or cytopenia.

Answer 12

non-hodgkins lymphoma

Question 13

waldeyers ring

Answer 13

non hodgkins lymphoma

Question 14

give high dose chemo (R-CHOP) therapy, as opposed to radation to which oma?

Answer 14

non-hodkings lymphoma

Question 15

reed sternberg cells (owl eyes)

Answer 15

hodgkins lymphoma

Question 16

what CD is expressed in hodgkins, and what drug can you give for it?

Answer 16

CD20, give rituximab

Question 17

caused by environmental factors (smoking, chemicals, tobacco)

Answer 17

acute myeloid leukemia

Question 18

anemia, neutropenia, and thrombocytopenia with aching in long bones

Answer 18

AML

Question 19

retainal hemmorages and whitish plques

Answer 19

AML

Question 20

auer bodies, auer rods

Answer 20

AML

Question 21

these patients may have a dry tap on bone aspiration

Answer 21

AML

Question 22

how many blasts must be present in total cells on aspiration to dx AML? (in percentage)

Answer 22

20%

Question 23

a kid with AML versus an old lady over 60, how does treatment vary?

Answer 23

do everything to keep the kids alive, LOLs can just keep them at bay and avoid remission.

Question 24

drug to give to AML for supportive care

Answer 24

Hydroxyurea

Question 25

Blast CRISIS

Answer 25

Chronic myelogenous leukemia

Question 26

Ionizing radiation

Answer 26

CML

Question 27

WBC > 100,000 and Platelet > 600,000

Answer 27

CML

Question 28

the big 3 to diagnose CML

Answer 28

high platelet, Ph+, myelocyte bulge

Question 29

while waiting for flow to come back with CML, do what?

Answer 29

Give hydroxyurea to lower the WBC count.

Question 30

but most people with CML blast crisis people are put on.

Answer 30

TKIs (mabs)

Question 31

ALL kids are chunky means....

Answer 31

Acute lymphocytic leukemia happens commonly in kids, showing chucky cells on periodic acid shiff staining.

Question 32

If the ALL is B cell, you will see....

Answer 32

anemia, Tcpenia, neutropenia....and CD20!!!

Question 33

if the ALL is T cell, you will see....

Answer 33

lymphadenopathy, mediastinal mass..and LDH!!

Question 34

what you really need to dx ALL

Answer 34

blasts in peripheral smear from blood, marrow, or tissue, and GET THE FLOW

Question 35

what additional cavity can we check for blasts in ALL?

Answer 35

intrathecal

Question 36

down syndrome

Answer 36

acute lymphocytic leukemia

Question 37

mucositis

Answer 37

acute lymphocytic leukemia

Question 38

treatments for ALL kids

Answer 38

PO hydroxy, POP proph, OCPs, oral hygiene, supplements, antiemetics, pain control, rescue meds, depression screning, sunscreen.