last minute 'omas Flashcards

1
Q

bone pain (usually in the back or chest) with anemia

A

multiple myeloma

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2
Q

pathologic fractures

A

multiple myeloma

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3
Q

Bence Jones proteinuria

A

Multiple myeloma

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4
Q

High calcium, LDH and uric acid

A

multiple myeloma

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5
Q

osteolytic lesions

A

multiple myeloma

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6
Q

3 criteria to dx mm

A

presence of monoclonal protein
presence of plasma b cells in marrow
end organ damage such as (increased Ca2+, lytic bone lesions, anemia, or renal failure)

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7
Q

Bortezomib

A

multiple myeloma

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8
Q

in multiple myeloma you can also give what which can cause ONJ

A

bisphosphonates

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9
Q

high tumor burden

A

lymphoma

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10
Q

itching

A

lymphoma

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11
Q

to diagnose lymphoma you need to…

A

biopsy the node and phenotype it.

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12
Q

its either aggressive with systemic b syptoms or indolent with slow growing LAN, hepatosplenomegaly, or cytopenia.

A

non-hodgkins lymphoma

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13
Q

waldeyers ring

A

non hodgkins lymphoma

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14
Q

give high dose chemo (R-CHOP) therapy, as opposed to radation to which oma?

A

non-hodkings lymphoma

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15
Q

reed sternberg cells (owl eyes)

A

hodgkins lymphoma

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16
Q

what CD is expressed in hodgkins, and what drug can you give for it?

A

CD20, give rituximab

17
Q

caused by environmental factors (smoking, chemicals, tobacco)

A

acute myeloid leukemia

18
Q

anemia, neutropenia, and thrombocytopenia with aching in long bones

19
Q

retainal hemmorages and whitish plques

20
Q

auer bodies, auer rods

21
Q

these patients may have a dry tap on bone aspiration

22
Q

how many blasts must be present in total cells on aspiration to dx AML? (in percentage)

23
Q

a kid with AML versus an old lady over 60, how does treatment vary?

A

do everything to keep the kids alive, LOLs can just keep them at bay and avoid remission.

24
Q

drug to give to AML for supportive care

A

Hydroxyurea

25
Blast CRISIS
Chronic myelogenous leukemia
26
Ionizing radiation
CML
27
WBC > 100,000 and Platelet > 600,000
CML
28
the big 3 to diagnose CML
high platelet, Ph+, myelocyte bulge
29
while waiting for flow to come back with CML, do what?
Give hydroxyurea to lower the WBC count.
30
but most people with CML blast crisis people are put on.
TKIs (mabs)
31
ALL kids are chunky means....
Acute lymphocytic leukemia happens commonly in kids, showing chucky cells on periodic acid shiff staining.
32
If the ALL is B cell, you will see....
anemia, Tcpenia, neutropenia....and CD20!!!
33
if the ALL is T cell, you will see....
lymphadenopathy, mediastinal mass..and LDH!!
34
what you really need to dx ALL
blasts in peripheral smear from blood, marrow, or tissue, and GET THE FLOW
35
what additional cavity can we check for blasts in ALL?
intrathecal
36
down syndrome
acute lymphocytic leukemia
37
mucositis
acute lymphocytic leukemia
38
treatments for ALL kids
PO hydroxy, POP proph, OCPs, oral hygiene, supplements, antiemetics, pain control, rescue meds, depression screning, sunscreen.