last minute 'omas Flashcards
bone pain (usually in the back or chest) with anemia
multiple myeloma
pathologic fractures
multiple myeloma
Bence Jones proteinuria
Multiple myeloma
High calcium, LDH and uric acid
multiple myeloma
osteolytic lesions
multiple myeloma
3 criteria to dx mm
presence of monoclonal protein
presence of plasma b cells in marrow
end organ damage such as (increased Ca2+, lytic bone lesions, anemia, or renal failure)
Bortezomib
multiple myeloma
in multiple myeloma you can also give what which can cause ONJ
bisphosphonates
high tumor burden
lymphoma
itching
lymphoma
to diagnose lymphoma you need to…
biopsy the node and phenotype it.
its either aggressive with systemic b syptoms or indolent with slow growing LAN, hepatosplenomegaly, or cytopenia.
non-hodgkins lymphoma
waldeyers ring
non hodgkins lymphoma
give high dose chemo (R-CHOP) therapy, as opposed to radation to which oma?
non-hodkings lymphoma
reed sternberg cells (owl eyes)
hodgkins lymphoma
what CD is expressed in hodgkins, and what drug can you give for it?
CD20, give rituximab
caused by environmental factors (smoking, chemicals, tobacco)
acute myeloid leukemia
anemia, neutropenia, and thrombocytopenia with aching in long bones
AML
retainal hemmorages and whitish plques
AML
auer bodies, auer rods
AML
these patients may have a dry tap on bone aspiration
AML
how many blasts must be present in total cells on aspiration to dx AML? (in percentage)
20%
a kid with AML versus an old lady over 60, how does treatment vary?
do everything to keep the kids alive, LOLs can just keep them at bay and avoid remission.
drug to give to AML for supportive care
Hydroxyurea