Last min Flashcards

1
Q

Seborrhoeic dermatitis - first-line treatment is

A

topical ketoconazole

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1
Q

A 38-year-old woman with a 4.5cm fibroid has been listed for a myomectomy following a 5 month history of heavy menstrual bleeding.
What drug should be prescribed to be taken whilst awaiting surgery?

A

For patients with uterine fibroids, GnRH agonists may reduce the size of the fibroid but are typically useful for short-term treatment

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2
Q

Acute heart failure not responding to treatment -

A

consider CPAP

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3
Q

which bacterial infection common after influenza

A

staphylococcus aureus

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4
Q

Whooping cough management

A
  • azithromycin or clarithromycin if the onset of cough is within the previous 21 days
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5
Q

Nancy, 72, is diagnosed with chronic obstructive pulmonary disease (COPD). Despite using a short-acting beta agonist along with a short-acting muscarinic antagonist, she is still breathless at rest. Her current FEV1 is found to be 45%.

On reviewing the full blood count she had at the time of diagnosis you note a raised eosinophil count.
Which of the following would be the most appropriate next step in her management?

A.	Long acting beta agonist	
B.	Inhaled corticosteroid	
C.	Inhaled corticosteroid and long-acting muscarinic antagonist	
D.	Inhaled corticosteroid and long-acting beta agonist	
E.	Long-acting beta agonist and Long acting muscarinic antagonist
A

D. Inhaled corticosteroid and long-acting beta agonist

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6
Q

A 12 day old infant is brought to the emergency department by his anxious mother who notices that he has developed a right sided groin swelling. On examination the testes are correctly located but it is evident that the child has a right sided inguinal hernia. It is soft and easily reduced.
What is the most appropriate management?

A.	Surgery over the next few days
B.	Reassure and discharge	
C.	Surgery at 1 year of age	
D.	Surgery once the child is 6 months old	
E.	Application of a hernia truss
A

A. Surgery over the next few days

Inguinal hernia in infants = Urgent surgery

The high incidence of strangulation necessitates an urgent herniotomy be performed. In infants with a reducible hernia this can be performed on a daycase list during the same week. Deferring surgery on the basis of age is not justified.

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7
Q

A 56-year-old gentleman is brought in by paramedics. The patient fainted this morning and has not regained consciousness. No injuries reported from his faint. On examination his heart rate is 37 beats/minute, respiratory rate is 16 breaths/minute, blood pressure is 105/70 mmHg. The ambulance crew gave the patient six doses of IV atropine while on route to the hospital. You order an ECG:

The ECG shows prolonged PR interval.
What would be the initial management?

A.	Synchronised cardioversion	
B.	Implant pacemaker
C.	IV amiodarone
D.	External pacing	
E.	IV adenosine
A

External pacing is used for symptomatic bradycardia if atropine fails

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8
Q

A 42-year-old woman falls off her horse and sustains a head injury. A CT scan on admission to the Emergency Department demonstrates a skull fracture and an associated extra-dural haematoma overlying the left parietal lobe. She has a Glasgow coma score of 12; E3 V4 M5, on arrival with no apparent neurological deficits. At the time both pupils are 4mm in diameter with intact pupillary light responses. She deteriorates within an hour to a Glasgow coma score of 8; E2 V2 M4. Her left pupil is now fixed at 7mm and her right pupil is 3mm and reacts to light. Additionally, her left eye is deviated inferiorly and away from the midline.
What is the most likely pathology responsible for her clinical findings?

A.	Trans-tentorial herniation	
B.	Cerebellar tonsillar herniation	
C.	Posterior communicating artery aneurysm	
D.	Frontal eye field injury	
E.	Optic nerve compression
A

Trans-tentorial herniation

Raised ICP can cause a third nerve palsy due to herniation

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9
Q

IgA nephropathy vs Post-streptococcal

A

IgA- presents within days
Post-strep- presents 1-2 weeks after

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10
Q

The three criteria for aneurysm surgery are:

A
  • An asymptomatic aneurysm larger than 5.5 cm in diameter.
  • An asymptomatic aneurysm which is enlarging by more than 1 cm per year.
  • A symptomatic aneurysm. This is the only criteria, apart from emergency rupture, which requires urgent surgery rather than an elective procedure.
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11
Q

A patient who presents to their GP within 7 days of a clinically suspected TIA should have

A

300mg aspirin immediately (and be referred for specialist review within 24h)

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12
Q

You have been called to see a 36-year-old lady, Saira, on the acute medical admissions ward. The nurse started her blood transfusion two minutes ago, and now Saira is complaining of chills, abdominal and chest pain and dizziness. On examination, you cannot visualise a rash or any angioedema, however, her blood pressure has fallen from 115/75 mmHg to 80/60 mmHg and her temperature has risen to 38ºC. She is beginning to become agitated.
Which one of the following management options would be most suitable to treat this patient?

A.	Temporary transfusion termination and an antipyretic	
B.	Permanent transfusion termination and high dose immune globulin therapy.	
C.	Permanent transfusion termination, generous fluid resuscitation with saline solution and inform the lab	
D.	Temporary transfusion termination and an antihistamine	
E.	Permanent transfusion termination, intramuscular adrenaline, corticosteroids and supportive care
A

Acute haemolytic transfusion reaction should be treated with generous fluid resuscitation and termination of the transfusion.

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13
Q

caput succedaneum vs cephalohaematoma

A

Caput succedaneum is a subcutaneous, extraperiosteal, collection of fluid that collects as the result of pressure on the baby’s head during delivery.

A cephalhaematoma is a haemorrhage between the skull and periosteum. Because the swelling is subperiosteal, it’s limited by the boundaries of the baby’s cranial bones.

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14
Q

when to 2 week wait a women with breast lump

A

women>30

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15
Q

A 78-year-old male is recovering on the ward following a partial thyroidectomy to remove a thyroid nodule 48 hours previously.

He complains of muscle cramps and a ‘tingling sensation’ around his mouth. An ECG is performed on the ward.
Given the likely cause of his symptoms, which of the following abnormalities may be observed on his ECG?

A.	Prolonged PR interval	
B.	Shortened ST segment	
C.	Prolonged QT interval	
D.	Tall, peaked T wave	
E.	ST elevation
A

Prolonged QT interval

Complications of thyroid surgery - damage to parathyroid glands can result in hypocalcaemia

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16
Q

management of reactive arthritis

A

ibuprofen

Acute reactive arthritis can be treated with NSAIDs, as long as there are no contraindications

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17
Q

A 30-year-old woman who is 41 weeks pregnant is being induced in the labour ward. She has an artificial rupture of membranes, but the midwife notices that the umbilical cord is visibly protruding from the vagina. She is brought for an emergency caesarean section.
What is the correct position for her to be in while being prepared for surgery?

A.	Flat on her back	
B.	McRobert's position	
C.	On her back with head lowered and lower half of bed raised	
D.	On her knees and elbows	
E.	Standing
A

The correct position for women who have a cord prolapse is on all fours, on knees and elbows

This is an example of cord prolapse, the majority of which occur after artificial rupture of membranes. The correct position for a woman to be in while being prepared for caesarean is on all fours (on knees and elbows), while someone pushes the presenting part of the fetus up. McRobert’s is a manoeuvre used during shoulder dystocia.

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18
Q

A 72-year-old gentleman is admitted to the emergency department with abdominal pain, nausea, fatigue, and confusion. He has a past medical history of stage IV lung cancer, diagnosed two months ago. Blood samples are taken and sent to the lab.
Given the most likely electrolyte abnormality, what would you most likely observe on this patient’s ECG?

A.	Prominent U waves	
B.	Tenting of the T-waves	
C.	Wide QRS complexes	
D.	Shortening of the QT interval	
E.	Osborne (J) waves
A

The main ECG abnormality seen with hypercalcaemia is shortening of the QT interva

This man is presenting with symptoms characteristic of hypercalcaemia, secondary to malignancy. The main ECG abnormality seen with hypercalcaemia is shortening of the QT interval. Osborne (J) waves may also be seen in more severe cases. If the hypercalcaemia is not corrected, ventricular arrhythmias like Ventricular Fibrillation can develop.

19
Q

What is the single most appropriate initial investigation(s) to assess for the presence of free fluid in the abdomen and chest?

A.	CT abdomen and CT chest	
B.	MRI abdomen and MRI chest	
C.	MRI abdomen and CT chest	
D.	Diagnostic peritoneal lavage	
E.	FAST scan
A

FAST scans can be used to assess the presence of fluid in the abdomen and thorax

While CT imaging is useful in the assessment of free fluid in the abdomen and chest of trauma patients, the most appropriate initial investigation to conduct is a focused assessment with sonography for trauma (FAST) scan. In the hands of a skilled practitioner, this can detect free fluid surrounding the kidneys, the spleen, the liver, bladder and pericardium. It is also possible to visualise all four chambers of the heart and to assess the hepatic vasculature. An extended focused assessment with sonography for trauma (eFAST) can be conducted, which also assesses for pneumothorax. The sensitivity of a FAST detecting a pneumothorax is 40%, however is considered more sensitive than a supine chest radiograph at detecting pneumothoraces.

20
Q

management of myxoedemic coma

A

thyroxine and hydrocortisone

21
Q

Thyrotoxic storm management is treated

A

with beta blockers, propylthiouracil and hydrocortisone

22
Q

Intrahepatic cholestasis of pregnancy

A

increases the risk of stillbirth; therefore induction of labour is generally offered at 37-38 weeks gestation

Ursodeoxycholic acid reduces itch and improves LFTs but does not reduce the risk of stillbirth

23
Q

Mr Wyle, a 69-year-old man has been brought to the emergency department by his wife. She is very concerned about his breathing. She says he has a background of COPD and he has been becoming progressively more breathless over the last 3 days with a productive cough and today she noticed that he was working hard to breath at rest. She says he has become even more breathless on the journey in to hospital.

You note that his oxygen saturations are 60% on room air. He is in the tripod position and using his accessory muscles to breathe. His lips have a blue tinge to them. You note that he has been admitted to hospital several months ago and that he is known to retain CO2.
Which of the following methods of oxygen delivery would be most suitable for Mr Wyle?

A.	Nasal cannulae	
B.	Simple face mask	
C.	28% venturi mask	
D.	15L via non-rebreathe mask	
E.	24% venturi mask
A

15l
Any critically ill patient (including CO2 retainers) should initially be treated with high flow oxygen which is then titrated to achieve target sats. Hypoxia kills

24
Q

A second drug should be added in type 2 diabetes mellitus if the HbA1c is

A

> 58 mmol/mol

25
Q

cardiac problems and citalopram

A

Citalopram is the most likely SSRI to lead to QT prolongation and Torsades de pointes

26
Q

Correcting sodium levels rapidly is dangerous:

A
  • Hyponatraemia correction - osmotic demyelination syndrome
  • Hypernatreamia correction - cerebral oedema
27
Q

A 40-year-old woman attends for a routine appointment for a review of her blood pressure. When attending for a blood test she was incidentally found to have a blood pressure of 160/80mmHg. She has completed a home blood pressure diary which shows similar results. There is no past medical history of note and she denies any additional symptoms. She is not currently taking any medications. Her body mass index (BMI) is 24kg/m2.

What is the most appropriate investigation to request?

A.	24 hour urine metanephrines	
B.	Renin-aldosterone ratio	
C.	Ultrasound of the kidneys	
D.	9am cortisol	
E.	Doppler of the renal arteries
A

A plasma aldosterone/renin ratio is the first-line investigation in suspected primary hyperaldosteronism

The most common secondary cause of hypertension is primary hyperaldosteronism (often called Conn’s syndrome). This tends to present with hypertension and hypokalaemia, although potassium can often be normal. The first line screening test is the renin-aldosterone ratio. Ideally, this should be taken whilst the patient is not taking any antihypertensives - if needed doxazosin is the only drug known not to affect the result.

28
Q

gold standard diagnosis for pulmonary fibrosis

A

high resolution CT

think fine inspiratory crackles

CHAARTS
RASIO

29
Q

describe

A

b) Distal radial fracture (1 mark) with dorsal angulation (1 mark) and dorsal displacement (1 mark)

MEDIAN NERVE AT RISK

30
Q

Bad medications for the elderly

A

Oxybutynin – this is an anticholinergic which should not be prescribed to the elderly and frailer as it can increase the risk of falls.

Furosemide – Dehydration can cause hypotension, low potassium (can cause fainting and general weakness), low sodium (confusion).

Tramadol – in the elderly there is an increased risk of unwanted side effects – constipation, dizziness, fainting, weakness, all of which could lead to adverse outcomes such as falls in an elderly patient.

Zopiclone – Z drug normally used for insomnia – increased sedative effect on Gwendolen, could lead to falls.

31
Q

assessing for risk of stroke

A

f) ROSIER – listed in the workbook. Don’t need to know the scoring points but know the name.

FAST is used in the community to identify stroke symptoms.

32
Q

complications of AA

A
  • retroperitoneal leak
  • aortoduodenal fistula - erosion of aortic wall into adjacent intestinal tract
  • emboli
33
Q

moa of tamsulosin in BPH

A

alpha-antagonist- Relax the muscles in the prostate and bladder neck, improving urine flow.

34
Q

moa of finesteride

A

5-Alpha Reductase Inhibitors: Finasteride and dutasteride can shrink the prostate gland over time by reducing levels of

35
Q

AKI staging

A
36
Q

management of hyperkalaemia

A
  1. Give Calcium Gluconate 10% IV (1 mark)
  • To stabilise myocardium - protect the heart
  1. Give Nebulised Salbutamol 20mg (1⁄2 mark) + Insulin (Actrapid) 10 units with Glucose 25mg IV ( (1⁄2 mark)
  • Shift of potassium back into cells to lower serum potassium] 0.9% NaCl 500ml IV Bolus (1 mark)
37
Q

why polycythaemia vera with RCC

A

Ectopic EPO

38
Q

why does RCC cause Left sided varicocele via

A

RCC mass compressing the left renal vein

39
Q

diagnosing chalmaydia and gonorrhea

A

c) Vulvovaginal swab with Nucleic acid amplification test (first pass urine sample in males with NAAT)

40
Q

examination finding AS

A

Schober’s Test (1 mark )
It examines flexion of the spine. (1⁄2 x 4)
1. Draw a line at the level of posterior superior iliac spine (1⁄2 marks)
2. Draw another line 10cm above PSIS line. Draw another line 5cm below
PSIS. (1⁄2 marks)
3. Ask patient to touch their toes and measure distance between top and bottom
line. (1⁄2 marks)
4. Less than 5cm in length with forward flexion - indicative of AS. (1⁄2 marks)

41
Q

pathophysiology of acne vulgaris

A
  • Triggered by androgens
  • Can have genetic and non-genetic (dietary, stress) factors
  • Psychosocial impact
  • Chronic inflammation in pilosebaceous units
  • with or without infection
  • Increased sebum production
  • Blockage of pilosebaceous units with keratin
42
Q

how is HIV monitored

A
  • **CD4 count: **This is a count of the number of CD4 cells in the blood. These are the cells destroyed by the HIV virus. The lower the count the higher the risk of opportunistic infection. 500-1200 cells/mm is the normal range. Under 200 cells/mm is considered end stage HIV / AIDS and puts the patient at high risk of opportunistic infections
  • Viral load is the number of copies of HIV RNA per ml of blood. “Undetectable” refers to a viral load below the labs recordable range (usually 50 – 100 copies/ml). The viral load can be in the hundreds of thousands in untreated HIV.
43
Q

testing for HIV

A
  • Antibody blood test. This is the typical test used in hospitals to screen for HIV. There is an option for patients to self sample by requesting a kit online and posting a sample of their blood to get tested for the antibody.
  • Testing for the p24 antigen, checking directly for this specific HIV antigen in the blood. This can give a positive result earlier in the infection compared with the antibody test.
44
Q

PEP

A

PEP commenced less than 72 hours after exposure
It involves a combination of ART therapy. The current regime is Truvada (emtricitabine / tenofovir) and raltegravir for 28 days.

45
Q

test for addisons

A

ACTH Stimulation Test (SynACTHen) (1 mark)

  • In Primary Adrenal Insuffiency, levels of cortisol do not increase adequately when given synthetic ACTH due to damaged adrenal glands (1 mark)
  • [Serum cortisol levels are checked before and 30min after administering 2500ug of synthetic ACTH. Can be given IV or IM.]
46
Q

management of Addisons

A

Hydrocortisone - Glucorticoid replacement

Fludrocortisone- Mineralocorticoid replacement