large datasets and cancer

Question 1

what is bioinformatics?

Answer 1

science of collecting and analysing complex biological data

Question 2

Advantages of next generation sequencing(NGS)?

Answer 2

Cheaper, quicker, more comprehensive methods to sequence dna/rna

Question 3

types of NGS

Answer 3

Illumina, Roche, ion torrent, oxford nanopore, SOLID sequencing

Question 4

Roche sequencing method and difference of Illumina?

Answer 4

take genome and fragment to smaller parts. Put onto beads and let multiple put on plate and take picture.
illumina doesnt use beads it has barcode that can be lit up

Question 5

less direct effects of a single mutation(excluding protein change)

Answer 5

change splicing of genes, modify structure of dna, modify structure of genome

Question 6

define translational bioinformatics

Answer 6

making use of data in clinical or industrial setting

Question 7

define chromothripsis

Answer 7

thousands of chromosome rearrangement occuring in localised and confined genomic regions