Large Animal Medicine II Exam I Flashcards
Number one cause in dairy cattle is phosphorus deficiency. Leads to fragile red blood cells and usually in cows on a lot of grass
Post partum hemoglobinuria
Caused by bovine coronavirus. Wild ruminants are reservoirs for the virus. 2-6 year old animals are at highest risk. Diagnosis by detection of virus with ELISA or RT-PCR. Samples must be collected 1-3 days of onset of diarrhea. Treat with fluids
Winter Dysentery
Treatment for anaplasma
Oxytetracycline, before replicative stage occurs in the cow so during the incubation stage
May occur in young calves when 1st weaned. Produced hypotonicity and leads to intravascular hemolysis
Water intoxication
Assosicated with lupine in western australia. Causes liver damage
Phomopsins
Test for digestion of carbohydrates in rumen fluid
Gluose fermentation test
Outcome of infection with BVD in pregnant animal depends upon
Stage of gestation Strain of BVDV Immune status of the cow
Dairy. Good for cheese
Jersey
Caused by feeding of rough fibrous feed during droughts or feeding machine made wheat. No feces, dehydration, anorexia, abdominal distension. Usually found on exploratory rumentomy.
Omasal impaction
Dose dependent infection, dependent of life cycle of parasite. Causes bloody diarrhea
Coccidiosis Eimeria bovis and Eimeria zuernii
Monocytes 1-5% in bovine means
Chronic disease
Attaches to villous enterocytes, decreases surface area and causes malabsoptive diarrhea. Resolution in 2 days
Rotavirus
Second most common deficiency of cattle. Secondary to molybdenum excess or from soil/plants
Copper
Primary impaction due to dry feed with limited water. Secondary impaction due to disturbances in motility or pyloric outflow failure. Results from TRP, Right displaced abomasum
Type III Vagal indigestion (Abomasal obstruction)
Purpose of fungus in the rumen
Aids bacteria in cellulose digestion.
NSAID that can be used as endotoxemic ridding effect in calves
Flunixin meglumine
NSAID of propionic acid class. Potent PGE2 inhibitor. Short half life and requires multiple doses
Ketoprofen
Treatment for calf e.coli
Remove organism from GI tract- Amoxicillin Correct dehydration Prevention with vaccine
Highly restricted class of antibiotics. ELDU is forbidden. Bactericidal. Concentration dependent. Inhibits bacterial DNA replication and transcription by binding the A subunit of DNA gyrase.
Fluoroquinolones
Affects older animals more severely. Calves can be carriers. Caused by rickettsial organism. Invades margin of RBCs. Transmitted by ticks and horse flies. Cattle and sheep are susceptible. Will have milk drop, icterus, aggression. First sign is presence of organism in RBCs.
Anaplasmosis A. marginale or A. caudatum
Produced by fungi. Grows on corn, peanuts, and cotton. Causes hepatic failure.
Aflatoxin
Physiological signs of pain
Increased respiration Increased HR Increased Body temperature Increased pupil size
Occur during periparturient period. Associated with LDAs, coliform mastitis, and metritis. Not severely affected, causes reduced food intake and milk production. Diagnosis only at necropsy
Type I abomasal ulcers.
Non perforating, non bleeding
Seen months after pasture exposure. Caused by simultaneous emergence of arrested larvae. Cattle appear normal and then death in 1-2 weeks
Type II ostertagia
Pathogenesis of rumen acidosis
Loss of body water causes dehydration contributing to acidosis. Lactic acid is absorbed from rumen as well as from small intestine and profound lactic acid develops.
Lethal at 0.3% BW. Glycoside toxin carboxyatractyloside causes severe hypoglycemia and massive hepatic necrosis. Young plants more toxic.
Cocklebur
Only NSAID approved for use in the US for cattle and swine. Labeled for fever/inflammation associated with respiratory disease, mastitis, and endotoxemia.
Flunixin meglumine
Restrictions for B lactams
Follow label for aminopenicillins. ELDY is permitted as long as AMDUCA is followed
Results from other disease. Chronic. Rumination is absent, rumen underfilled, fecal production is depressed, might have diarrhea
Secondary rumen indigestion
Asymmetric abdominal distension most pronounced in the left paralumbar fossa. Increased HR and RR. Acute form can cause death in 30 min to 4 hours
Bloat
Diarrhea with damage to villous epithelium and loss of enterocytes leading to shortening of the villi because loss is faster than replacement. Results in decreased suface area and enterocytes lost are mature and important. Viruses, bacteria, and protozoa are most commonly involved with this type of diarrhea
Malabsorptive diarrhea
Treatment for severe cases of SARA
Successful tx limited.
Empty rumen by oral lavage/rumenotomy.
Oral buffers
Fluid therapy
Management for frothy bloat
Grazing management
Polxalene (top dressing)
Ionophores
Least common displaced abomasum. 180 degree torsion with or without volvulus. Rotation along mesenteric axis. Outflow obstruction and schema if arteries obstructed.
Right displaced abomasum
Toxin: Abrin
Rosary Pea
Toxin: Robin. New growth is most toxic
Black locust
Fluoroquinolone used in swine
Just Enrofloxacin
Azalides consist of
Azithromycin, Tulathromycin, Gamithromycin, Tildipirosin
Caused by oral exposure to fecal coliforms that lead to colonization of the gut. 80% attachment occurs. Signs include secretory diarrhea and dehydration.
Enterotoxigenic E. Coli
Time dependent antibiotics. Bactericidal. Binds to penicillin binding proteins, Penems cause cell lysis. Poor intracellular activity
B lactams
Beef cow
Piedmontese.
Italian. Beef selected for myostatin gene
Causes of elevated rumen fluid chloride
Abomasal disease
Abomasal reflux
Obstruction of intestinal flow
Restrictions for Florfenicol
Extra label use is permitted. Prolonged withdrawal for different than labeled production class.
If non segmented neutrophils 0% seen on bovine WBC count
Indicates Acute overwhelming infection
A carcass with violative residues is condemned by
FSIS
Antibiotic selection has been proven to be based on
Production class and organ system affected
Instrument used to treat esophageal obstructions
Probang
Developmental stage for anaplasmosis lasts 4-9 days and
Most signs are present, lasts 3 weeks to 3 months, carrier state
Diagnosis for anaplasma
Complement fixation test
Inhibits COX isoenzymes lowering prostaglandin production from arachadonic acid.
NSAIDs
Number one risk factor for calve diarrhea
Colostrum deficiency. Failure of passive transfer.
Mostly acquired from systemic infection and end up with valvular vegetative endocarditis. Usually right side of heart.
Valvular heart disease
Brahma
Wooden tongue. Painful nodular lesions involving the soft tissues and oral cavity leading to swelling at the base of tongue. Examine pus for sulfar granules.
Actinobacillosis
Hepatotoxin found in plants. Cumulative and progressive. Problems 1-5 months after ingestion. Causes in-utero infections. Alkaloids damage hepatocytes leading to fibrosis. Neuro and liver signs
Pyrrolizidine alkaloids
Beef cow
Scotch Highland
Reduction in frequency or strength of primary contraction. Caused by reduction in excitatory drive to gastric center, increase in inhibitory inputs, and weakness of the motor pathway.
Hypomotlity of the primary mixing cycle
Provides large surface area for the absorption of VFAs, electrolytes, and water. Reduces feed particles. Located toward the right of the median plane and opposing the 7th and 11th ribs
Omasum
Bactericidal, concentration depended. Primarily aerobic Gram -. Highly water soluble. Oral absorption is poor after gut closure. Irreversibly binds to the 30s ribosome. Accumulates in lysosomes and mitochondria. Nephrotoxicity and ototoxicity.
Aminoglycosides
Used in swine. Avoid ruminants and horses because causes Clostridial overgrowth. Inhibits protein synthesis by binding the 50s ribosome. Used for mycoplasma pneumonias and bacterial arthritis. Can result in swelling of the anus
Lincosamides
Beef
King ranch
Animals eating 5% or more for over 30 days will die. Invasive weed. Causes pyrrolizidine toxicity
Tansy Ragwort
Oocyte shedding occurs as early as 3 days of age and peaks at 2 weeks. Can continue to occur if environment contaminated. Severe villous atrophy and malabsorptive diarrhea.
Cryptosporidium parvum
Best drug use for pain.
Multimodal drug use. Target acute pain with quick acting, short duration. Follow with long acting NSAIDs, opioids, local, NMDA receptor, a2 agonists.
Glycoproteins that bind to cell receptors causing inhibition of protein synthesis and cell death. Most toxic of known plant compounds. Concentrated in seeds and are released following chewing the seed. Cause severe intestinal irritiation and purgation.
Lectins (Castor bean, Rosary pea, Black locust)
A prescription basically for anti infectives added to feed. Must follow the label for mixing and feeding. Enforced by the FDA.
Veterinary feed directive
Discovered on King ranch. Parasite in RBCs. Eradicated from USA. Transmitted by Boophilus spp. tick. Animal develops disease at young age when not really susceptible but can develop immunity. Animal becomes carrier but is also resistant. Urine is dark red to brown color from hemoglobinuria.
Babesiosis (Texas Tick Fever)
If severe scours give less
Milk More electrolytes instead
Failure of eructation that results in free gas bloat and ruminal distention. Usually due to vagus nerve damage due to TRP
Type I Vagus Indigestion
Produce alpha 2 casein in milk
Guernsey
First stage of anaplasmosis lasts 3-8 weeks and ends with
Rise in body temp. Incubation phase
Abdominocentesis findings for traumatic reticulopericarditis
Increased WBC (PMN >6,000 nucleated cells)
Increased concentrations (>3g/dL)
Beef cow
Chiaiana
Italian
Restricitions on aminoglycosides
Only can really be used in fetal pigs (withdrawal is 40 days). Zero tolerance drug.
Diarrhea with secretion of water is greater than can be absorbed. Usually from hypersecretion from small intestinal crypts due to abnormal stimulation. Stimulation increases adenyl cyclase activity and production of cAMP within the cells. Most commonly caused by enterotoxins and rotavirus. More common type in neonates.
Secertory diarrhea
Control methods for free gas bloat
Temporary rumenotomy
Fix underlying issue
AUC/MIC dependent antibiotic. Broad spectrum and bacteriostatic. Binds to the 30s ribosome. Minimal affinity for mammalian ribosomes, and prevents protein synthesis. Wide distribution through tissues, mostly eliminated through kidney.
Tetracycline
These have zero tolerance for residues
Aminoglycosides EL drugs Approved drugs used in different class than labeled
These products cannot be used off label
EPA
Main reason for residue testing
Public health concern. Risk= consumption x risk/unit of consumption