lancosamides

Question 1

Outline the spectrum of activity of clindamycin

Answer 1

1) Bacteriostatic- Binds to ribosomes , inhibits cell wall protein synthesis
2) Gram-positive cocci and also anaerobes (Bacteroides fragilis)
3) is well concentrated in bone and excreted in bile and urine

Question 2

What indications is clindamycin used for?

Answer 2

1) Staphylococcal joint & bone infections
2) Intra-abdominal sepsis
3) Cellulitis
4) Skin & soft tissue infections

Question 3

What are the side effects associated with the use of clindamycin?

Answer 3

1) Antibiotic-associated colitis
2) Jaundice
3) Blood disorders
4) Steven-Johnson syndrome

Question 4

what are the monitoring requirements for clindamycin?

Answer 4

Hepatic & renal function - in infants and in longer than 10 days treatment

Question 5

Who should clindamycin be used in caution with?

Answer 5

1) Existing diarrhoea
2) Colitis more common in middle aged & elderly women, post-op
3) avoid in acute porphyrias

Question 6

what patient and carer advice should be given to those taking clindamycin?

Answer 6

Patients and their carers should be advised to discontinue and contact a doctor immediately if severe, prolonged or bloody diarrhoea develop

Question 7

what additional information should be provided to patients if they are using the cream

Answer 7

Damages latex condoms and diaphragms