Antimalarial treatment Flashcards
If the infective species is not known, or if the infection is mixed how should treatment progress?
as for falciparum malaria with quinine, Malarone® or Riamet®
should patients be treated even if the initial blood tests for the organism are negative?
considered in those with features of severe malaria as Falciparum malaria can progress rapidly
outline the treatment for Falciparum malaria
-falciparum is now resistant to chloroquine and Mefloquine dont give
1) Quinine, Malarone® or Riamet® given by mouth
2) Quinine should be given by IV infusion if very ill
what is the duration of treatment with quinine when treating Falciparum malaria?
1) Oral quinine is given by mouth for 5–7 days
2) Together with or followed by either doxycycline for 7 days or clindamycin for 7 days
If the parasite is likely to be sensitive what drugs should be given?
pyrimethamine with sulfadoxine as a single dose
Falciparum malaria is particularly dangerous in pregnancy, especially in the last trimester. what is the treatment?
1) Adult dose of oral and intravenous quinine can safely be given to pregnant women.
2) Clindamycin should be given after quinine
- avoid the other drugs in pregnancy
Non-falciparum malaria includes the following: Plasmodium vivax and less commonly by P. ovale and P. malariae. P. knowlesi . what is the treatment?
1) Chloroquine is the drug of choice for the treatment of non-falciparum malaria
2) in the case of P. vivax and P. ovale, a radical cure needed. This is achieved with primaquine given after chloroquine, for 14 days with the dose also dependent on the infecting organism
Parenteral If the patient is unable to take oral therapy for non-falciparum malaria, what are the options?
1) quinine by intravenous infusion,changed to oral chloroquine as soon as the patient’s condition permits.
how should non-falciparum malaria be managed in Pregnancy?
1) chloroquine can be given for non-falciparum malaria
2) In the case of P. vivax or P. ovale, the radical cure with postponed until the pregnancy is over; instead chloroquine should be continued, given weekly during the pregnancy.
