Lactate Journal

Question 1

What is metabolic flexibility?

Answer 1

The ability to appropriately adjust substrate oxidation relative to substrate availability.

Question 2

What is a substrate that could identify metabolic inflexibility?

Answer 2

Net Lactate release

Question 3

Why is lactate considered to be the nexus of glycolytic and oxidative metabolism?

Answer 3

b/c it is essentially shuttled between two major energy production pathways (glycolysis & oxidative phosphorylation)

Question 4

In healthy individuals at rest, what energy pathway supplies the majority of energy required?

Answer 4

Mitochondrial oxidation (beta oxidation)

Question 5

Elevated lactate can be an indication of what with regard to glycolysis?

Answer 5

Increased reliance on glycolysis.

Question 6

Is a dietary approach alone able to significantly influence fasting lactate levels?

Answer 6

No, Exercise training in conjunction with dietary strategies can reduce fasting lactate concentrations.

Question 7

What enzyme of anaerobic & aerobic metabolism plays a crucial role in metabolic flexibility of the muscle?

Answer 7

Pyruvate dehydrogenase

Question 8

In obese populations, a reduction in aerobic oxidation is observed, which leads to what compensatory metabolic pattern?

Answer 8

An over-reliance on glycolysis at rest.