Laboratory or Diagnostic Finding VS Disease Flashcards
Anticentromere antibodies
Scleroderma (CREST)
Anti-desmoglein (epithelial) antibodies
Pemphigus vulgaris (blistering)
Anti–glomerular basement membrane antibodies
Goodpasture syndrome (glomerulonephritis and hemoptysis)
Antihistone antibodies
Drug-induced SLE (e.g., hydralazine, isoniazid, phenytoin, procainamide)
Anti-IgG antibodies
Rheumatoid arthritis (systemic inflammation, joint pannus, boutonnière deformity)
Antimitochondrial antibodies (AMAs)
1° biliary cirrhosis (female, cholestasis, portal hypertension)
Antineutrophil cytoplasmic antibodies (ANCAs)
Microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (MPO-ANCA/ p-ANCA); granulomatosis with polyangiitis (Wegener; PR3- ANCA/c-ANCA)
Antinuclear antibodies (ANAs: anti-Smith and anti-dsDNA)
SLE (type III hypersensitivity)
Antiplatelet antibodies
Idiopathic thrombocytopenic purpura
Anti-topoisomerase antibodies
Diffuse systemic scleroderma
Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies
Celiac disease (diarrhea, weight loss)
“Apple core” lesion on barium enema x-ray
Colorectal cancer (usually left-sided)
Atypical lymphocytes
EBV
Azurophilic peroxidase (+) granular inclusions in granulocytes and myeloblasts
Auer rods (AML, especially the promyelocytic [M3] type)
Bacitracin response
Sensitive: S. pyogenes (group A); resistant: S. agalactiae
group B
“Bamboo spine” on x-ray
Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27)
Basophilic nuclear remnants in RBCs
Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)
Basophilic stippling of RBCs
Lead poisoning or sideroblastic anemia
Bloody or yellow tap on lumbar puncture
Subarachnoid hemorrhage
“Boot-shaped” heart on x-ray
Tetralogy of Fallot (due to RVH)
Branching gram-positive rods with sulfur granules Bronchogenic apical lung tumor on imaging
Actinomyces israelii
“Brown” tumor of bone
Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)
Cardiomegaly with apical atrophy
Chagas disease (Trypanosoma cruzi)
Cellular crescents in Bowman capsule
Rapidly progressive crescentic glomerulonephritis