Laboratory Analysis Of Hemostatic Mechanisms

Question 1

Which factors are vitamin k dependent

Answer 1

II, VII, IX, and X

Question 2

Explain the regulatory mechanisms of homeostasis

Answer 2

Normal fibrinolytic mechanisms. Normal endothelial lining. Plasma proteins C, S and Z

Question 3

Explain the dissolution of the fibrin clot

Answer 3

The clot serves as a temporary structure until the damaged area heals. The clot is then digested by the action of enzymes. Upon activation, plasmin acts enzymatically to break down fibrinogen and fibrin in the clot. Creating fragments

Question 4

Name three tests for evaluating hemostatic function

Answer 4

Prothrombin time
Activated partial thromboplastin time
Platelet count

Question 5

Discuss the role of prothrombin in blood coagulation

Answer 5

Prothrombin is transformed into thrombin by a clotting factor known as factor X or prothrombinase; thrombin then acts to transform fibrinogen, also present in plasma, into fibrin, which, in combination with platelets from the blood, forms a clot

Question 6

Explain the major use of a prothrombin time test

Answer 6

Evaluates the function of the extrinsic and common pathways of hemostais. The major use is to monitor warfarin anticoagulant therapy. Also as a presurgery coagulation screening test

Question 7

Explain the principle of the aptt

Answer 7

It’s a coagulation test used to monitor low dose heparin therapy and to screen for function of the intrinsic and common pathways.

Question 8

List twelve coagulation factors

Answer 8

I, II, III, formerly named IV, V, VII, VII:C, IX, X, XI, XII, XIII