Lab2 Inflammation and Repair Images

Question 1

What is this? What are the purple cells?

Answer 1

Acute inflammation

characterized by presence of neutrophils

Question 2

What is this?

Answer 2

Chronic inflammation

You can see presence of lymphocytes and plasma cells

Question 3

What is this? What are the arrows indicating?

Answer 3

Evolving pnemonia

Top arrow: edema and inflammatory cells

Bottom arrow: vascular congestion secondary to increase blood flow initially, follwed by stasis

Question 4

What is this? What type of exudate is this?

Answer 4

Acute pneumonia as shown by neutrophils within alveolar spaces

Example of purulen exudate

Question 5

What is the arrow point to? How would you characterize this inflammation of the pleura

Answer 5

Fibrinous pleuritis

Acute inflammation of pleura with fibrin on the surface

Question 6

What is the arrow pointing to?

Answer 6

An ulcer

An area of mucosal loss associated with acute inflammation and necrosis

Question 7

What is this central area called? What type of inflammation? Hint – a possible outcome of pneumonia

Answer 7

Pulmonary abscess formation

This is one possible outcome of acute inflammation

An abscess is a localize collection of pus associated with destruction of underlying normal tissue

Suppurative inflammation

Question 8

What does this represent? And what are these cells?

Answer 8

black arrows: plasma cells with eccentric nucleus, adjacent pale area

green arrows: lymphocytes with single nucleus filling most of cell

Question 9

What kind of cell is this?

Answer 9

Eosinophil

Question 10

What does this show? What is the big blob in the center?

Answer 10

Granuloma comprised of epithelioid histiocytes

Giant cells [langhans type] are in center

Question 11

What is this? How can you tell?

Answer 11

Granulation tissue

Endematous tissue and new capillaries forming

Question 12

What type of cell is this?

Answer 12

Myofibroblast

Expresses antigens of smooth muscle

responds to agents that contract smooth muscle

responsible for wound contraction

Question 13

What is this? What are the arrows?

Answer 13

This is the early stage of a scar

The arrows in clockwise order starting top left:

• re-epithelialization
• scale crust
• granulation tissue

Question 14

What is this?

Answer 14

This is granulation tissue

the left arrow is new blood vessel formation

The right arrow is endematous stroma

Question 15

What is this?

Answer 15

Late scar

You can tell from the fibrosis and collagen depostion

Fewer capillaries

Question 16

What does the arrow point to?

Answer 16

Thin new epidermis forming above a scar

Re-epithelialization

Question 17

What is this?

Answer 17

thick collagen bundles in keloid scar

Question 18

what is this

Answer 18

Keloid scar

Question 19

What type of cell does this point to?

Answer 19

Neutrophil

Question 20

What type of inflammatory cell does this show?

Answer 20

Neutrophils!

Question 21

What type of cells are these?

Answer 21

A = lymphocyte - dark stained nucleus, little cytoplasm

B = neutrophil

Lymphocyte is smaller than neutrophil

Question 22

What type of inflammatory cells here?

Answer 22

Lymphocytes

Question 23

What type of cell? How do you know?

Answer 23

plasma cell

clock-face nucleus

peri-nuclear halo = large golgi

Question 24

What type of cells do arrows point to?

Answer 24

plasma cells

Question 25

What is happening in this abnormal lung?

Answer 25

- alveolar spaces that normally contain air are filled with cellular infiltrate

Question 26

What are the arrows pointing to in acute inflammation of the lung?

Answer 26

blood vessels dilated and backed with RBCs due to increased blood flow and vascular permeability called congestion

Question 27

What are the pink strands the arrow is pointing to in this inflammatory response? What does it indicate?

Answer 27

Fibrin presence of fibrin in extravascular space indicated increased vascular permeability [normally cannot get through vessel wall]

Question 28

What kind of inflammatory cells are in this infection? Acute or chronic?

Answer 28

mostly lymphocytes and plasma cells chronic infection

Question 29

What kind of connective tissue in this infection? Why did it form?

Answer 29

Dense fibrous tissue Fibrosis often accompanies chronic inflammation --\> scar

Question 30

What do the white circle and arrows point to?

Answer 30

white circle = granuloma green arrow = epithelioid histiocytes [macrophages] red arrow = multinucleated giant cell yellow arrow = lymphocytes

Question 31

What is this called? What type of necrosis? Likely cause?

Answer 31

Granuloma = Caseous necrosis TB

Question 32

Arrows point to injured myocardial cells. Circles point to inflammatory cells. Describe the cellular changes? Type of cell death?

Answer 32

hypereosinophilic myofibers loss of nuclei [karyolysis] coagulative necrosis?

Question 33

Can you see any residual myocardial fibers? type of tissue? What do the arrows point to in this section of the myocardium?

Answer 33

- no myocardial fibers loose fibrous connective tissue containing edema + blood - thin walled blood vessels

Question 34

Stain of myocardium following MI with immunoperoxidase stain CD31 to mark endothelial cells [in brown]. What are the structures? What type of tissue?

Answer 34

structures are capillaries being formed this is granulation tissue

Question 35

This appearance of the liver is a sign of what?

Answer 35

Cirrhosis