Lab Investigation Of Full Blood Count And White Cell Disorders

Question 1

Where are blood cell produced?

Answer 1

Bone marrow of long bones

Question 2

Where are blood cells found?

Answer 2

mature in bone marrow and mature blood cells found in peripheral blood

Question 3

What is in red blood count within full blood count?

Answer 3

Hb - haemoglobin conc
Hct - percentage of red blood cells in blood volume
MCV - mean cell volume (size)
MCH - mean cell haemoglobin
RDW - range of deviation around rbc size
Reticulocyte count
Blood film

Question 4

What is else is in full blood count apart from red blood cell results?

Answer 4

Total WBC and each type
Neutrophils, lymphocytes, monocytes, basophils and eosinophils

Platelet count and size

Cells that shouldn’t be present

Question 5

What 2 things does a blood film show?

Answer 5

Numbers - low or high

Morphology if normal + cells that shouldn’t be present

Question 6

What can be seen in morphology of red blood cellss

Answer 6

Size, colour for Hb content, shape, polychromasia (blue colour) and other bodies

Question 7

What can be seen in morphology of white blood cells?

Answer 7

Numbers
Normal morphology - features
Immature cells (precursors)
Abnormal cells e.g. blasts
other bodies

Question 8

What are the advantages of automated haematology analyser?

Answer 8

efficient and cost effective
accurate an dprecise in quantitative blood test
can perform multiple tests
reduce labour

Question 9

What are the disadvantages of automated haematology analyser?

Answer 9

Flagging lab results in labour intensive
CANT SEE RED BLOOD CELL MORPHOLOGY ONLY WHITE BLOOD CELLS morphology
Platelet clumps are counted as single and say low count
Expensive with high running cost

Question 10

What is anisocytosis?

Answer 10

unequal red blood cell cycle - size of RBC morphology

Question 11

What are examples of abnormal shape morphology of rbc?

Answer 11

ellipotocytes, poikilocytes

Question 12

Why does polychromasia happen?

Answer 12

baby rbs have residual rna so they pick p stain differently appearing more blue/purple

Question 13

What is on a blood film showing iron deficiency anaemia?

Answer 13

Ovalocytes/elliptocytes
Pale cells - hypochromic
Scrappy cells

Question 14

What is on a blood film showing macrocytic megaoblastic anaemia?

Answer 14

Big cells

• gasterectomy so not intrinsic factor made in parietal cells in stomach. patient needs to take b12 supplements

Question 15

hat is on a blood film showing acquired haemolytic anaemia?

Answer 15

Spherocytes - round with no pale middle
Polychromasia - lots of reticulotytes (trying to recompensate so no problem in bone marrow) e.g jaundice so cells die quickly