Lab Intro Flashcards
Sytematic study of biochemical processes associated with health and disease
Clinical chemistry
Measurement of constituents in body fluids or tissues to facilitate diagnosis of disease
Clinical chemistry
Give 2 roles of MTs
- Deliver accurate and precise laboratory information
2. Provide reliable lab results
Categories of substances measured
- Substances with function in the circulation
- Metabolites
- Substances released from cells (cell damage/abnormal permeability/abnormal cellular proliferation)
- Drugs and toxic substances
non-functioning waste products in the process of being cleared
metabolites
comprehensive set of policies and procedures
quality assurance
monitors quality performance starting from the ordering of a lab determination to its reporting, the interpretation of results, and then application of patient care
quality assurance
test ordering & specimen collection
Pre-analytical phase
specimen transport to the lab
Pre-analytical phase
entering patient information
Pre-analytical phase
specimen processing
Pre-analytical phase
delivery to proper lab location
Pre-analytical phase
specimen analysis (manual or automated)
Analytical phase
pipette required specimen volume
Analytical phase
prepare PFF (protein free filtrate)
Analytical phase
add coloring reagent and incubate mixture
Analytical phase
measure absorbance and/or percentage transmission using spectrophotometer
Analytical phase
Commercial controls
Analytical phase
test results validation
Analytical phase
reporting out specimen results (manuel or computerized)
Post analytical phase
physician contact
Post analytical phase
concerned with analytical phase of QA
Quality control
Quality control relies on the diligent and persistent execution of the 4 activities
- Assay of control samples
- Instrument maintenance
- Statistical data analysis
- Proficiency testing survey
analytical error
Systematic error
personal or operator errors
Random
caused by some factors in the analytical system
Systematic error
usually affect a few analyses
Random error
solutions with a known amount of a substance and are used to calibrate an assay method
Reference materials
chemically pure standard
Primary reference materials
prepared from the primary standards
Secondary standards
