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Clinical Chemistry II > Bilirubin Determination > Flashcards

Bilirubin Determination Flashcards

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1
Q

end product of Hb catabolism

A

Bilirubin

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2
Q

Give 5 liver functions

A
  1. Metabolic
  2. Detoxification/conjugation
  3. Storage
  4. Excretory function
  5. Synthetic function
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3
Q

Bilirubin is for?

A

liver function test

  • secretory
  • excretory
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4
Q

Enumerate 4 proteins in bilirubin

A

myoglobin
cytochrome
peroxidase
catalase

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5
Q

condition due to increase of bilirubin in the circulation

A

jaundice

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6
Q

Pre-hepatic jaundice is also known as?

A

hemolytic hyperbilirubinemia

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7
Q

Hepatic jaundice is also known as?

A

hepatocellular hyperbilirubinemia

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8
Q

Post-hepatic anemia jaundice is also known as?

A

obstructive hyperbilirubinemia

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9
Q

excessive RBC destruction

A

Pre-hepatic anemia

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10
Q

Examples of excessive RBC destruction

A

Malaria

HA

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11
Q

excessive amount of bilirubin presented to the liver for metabolism

A

Pre-hepatic jaundice

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12
Q

Increased unconjugated bilirubin

A

Pre-hepatic anemia

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13
Q

impaired cellular uptake & defective conjugation

A

Hepatic jaundice

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14
Q

abnormal secretion of bilirubin

A

Hepatic jaundice

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15
Q

3 diseases that cause hepatic jaundice

A

viral hepatitis
liver cirrhosis/Laennec’s cirrhosis
Fasciola hepatica

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16
Q

liver cirrhosis is also known as?

A

Laennec’s cirrhosis

17
Q

Increased B1 & B2

A

Hepatic jaundice

18
Q

impaired secretion of bilirubin caused by mechanical obstruction of the flow of bile into the intestines

A

Post-hepatic jaundice

19
Q

gallstones disease

A

cholecystolithiasis

20
Q

stones in common bile duct

A

choledocholithiasis

21
Q

color of stool when normal source of pigmentation is lost

A

clay or gray colored

22
Q

In post hepatic, _____ may be decreased or absent

A

urobilinogen

23
Q

Increased B2/conjugated

A

post-hepatic jaundice

24
Q

bilirubin precursor

A

biliverdin

25
Q

Biliverdin enzyme to convert into unconjugated bilirubin

A

biliverdin reductase

26
Q

transport proteins

A

ligandin & z-protein

27
Q

Urobilinogen percentages and final destination

A

20%: portal circulation: urobilin

80%: stercobilin

28
Q

Give 5 inherited disorders of metabolism

A
  1. Gilbert syndrome
  2. Crigler Najjar
  3. Lucey-Driscoll
  4. Dubin Johnson
  5. Rotor syndrome
29
Q

Crigle Najjar Type

a. defective/decreased UDP-GT
b. absent UDP-GT

A

a. Type I

b. Type II

Clinical Chemistry II (4 decks)

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