Bilirubin Determination Flashcards
end product of Hb catabolism
Bilirubin
Give 5 liver functions
- Metabolic
- Detoxification/conjugation
- Storage
- Excretory function
- Synthetic function
Bilirubin is for?
liver function test
- secretory
- excretory
Enumerate 4 proteins in bilirubin
myoglobin
cytochrome
peroxidase
catalase
condition due to increase of bilirubin in the circulation
jaundice
Pre-hepatic jaundice is also known as?
hemolytic hyperbilirubinemia
Hepatic jaundice is also known as?
hepatocellular hyperbilirubinemia
Post-hepatic anemia jaundice is also known as?
obstructive hyperbilirubinemia
excessive RBC destruction
Pre-hepatic anemia
Examples of excessive RBC destruction
Malaria
HA
excessive amount of bilirubin presented to the liver for metabolism
Pre-hepatic jaundice
Increased unconjugated bilirubin
Pre-hepatic anemia
impaired cellular uptake & defective conjugation
Hepatic jaundice
abnormal secretion of bilirubin
Hepatic jaundice
3 diseases that cause hepatic jaundice
viral hepatitis
liver cirrhosis/Laennec’s cirrhosis
Fasciola hepatica
liver cirrhosis is also known as?
Laennec’s cirrhosis
Increased B1 & B2
Hepatic jaundice
impaired secretion of bilirubin caused by mechanical obstruction of the flow of bile into the intestines
Post-hepatic jaundice
gallstones disease
cholecystolithiasis
stones in common bile duct
choledocholithiasis
color of stool when normal source of pigmentation is lost
clay or gray colored
In post hepatic, _____ may be decreased or absent
urobilinogen
Increased B2/conjugated
post-hepatic jaundice
bilirubin precursor
biliverdin
Biliverdin enzyme to convert into unconjugated bilirubin
biliverdin reductase
transport proteins
ligandin & z-protein
Urobilinogen percentages and final destination
20%: portal circulation: urobilin
80%: stercobilin
Give 5 inherited disorders of metabolism
- Gilbert syndrome
- Crigler Najjar
- Lucey-Driscoll
- Dubin Johnson
- Rotor syndrome
Crigle Najjar Type
a. defective/decreased UDP-GT
b. absent UDP-GT
a. Type I
b. Type II
