Lab Exam 4 Nerves Flashcards
Nervous System Anatomical Subdivisions:
central nervous system (CNS)
peripheral nervous system (PNS)
central nervous system (CNS)
→brain and spinal cord enclosed and protected by cranium and vertebral column
peripheral nervous system (PNS)
nerves and ganglia
nerve
• bundle of nerve fibers (axons) wrapped in fibrous connective tissue
ganglion (plural, ganglia)
knotlike swelling in a nerve where the cell bodies of neurons are concentrated
Overview of the Nervous System
Endocrine and nervous systems maintain internal coordination/homeostasis
Endocrine system
communicates by means of chemical messengers (hormones) secreted into to the blood
Nervous system
employs electrical and chemical means to send messages from cell to cell
Nervous System—Coordination steps
- Sense organs and simple sensory nerve endings, receives information about changes in the body and external environment and transmits coded messages to the central nervous system (CNS)
- The CNS processes this information, relates it to past experience, and determines what response, if any, is appropriate to the circumstances
- The CNS issues commands primarily to muscle and gland cells to carry out such responses
Peripheral Nervous System Divisions
sensory (afferent) division
motor (efferent) division
Sensory afferent division does what and broken down into 2 more divisions
carries signals from receptors (sense organs and simple sensory nerve endings) to the CNS
Somatic sensory division
Visceral sensory division
Somatic Sensory Division does what
• carries signals from receptors in the skin, muscles, bones, and joints
visceral sensory division does what
•carries signals mainly from the viscera of the thoracic and abdominal cavities
The motor (efferent) division and broken down further into two more divisions
carries signals from the CNS to gland and muscle cells (effectors) that carry out the body’s responses
Somatic motor division
Visceral motor division (autonomic nervous system ANS)
Sympathetic division
Parasympathetic division
somatic motor division
carries signals to the skeletal muscles
muscular contractions→voluntary control
somatic reflexes→involuntary control
visceral motor division (autonomic nervous system, ANS)
sympathetic division
parasympathetic division
carries signals to glands, cardiac muscle, and smooth muscle→visceral reflexes (unconscious)
• sympathetic division tends to arouse the body for action
• parasympathetic division tends to have a calming effect
Nervous Tissue
specialized for communication by means of electrical and chemical signals.
• Neurons (nerve cells): detect stimuli, respond quickly, and transmit coded information rapidly to other cells
• Neurosoma (cell body)→nucleus and organelles; usually gives rise to a few thick processes that branch into a vast number of dendrites
• Neuroglia (glial cells): protect and assist the neurons
Dendrites
• branched processes that receive signals from other cells primary site for receiving signals from other neurons.
• Some neurons have only one dendrite and some have thousands
• more dendrites a neuron has, more information it can receive and incorporate into its decision making
An axon
is specialized for rapid conduction of nerve signals to points remote from the soma
Its cytoplasm is called the axoplasm and its membrane the axolemma
Schwann cells and myelin sheath that enclose the axon
At the distal end, an axon usually has a terminal arborization—an extensive complex of fine branches
• Each branch ends in a synaptic knob (terminal button), a little swelling that forms a junction (synapse) with the next cell
• It contains synaptic vesicles full of neurotransmitter
Supportive Cells (Neuroglia)
Glial cells (neuroglia) protect the neurons and help them function
Bind neurons together and provide a supportive framework for the nervous tissue
Wherever a mature neuron is not in synaptic contact with another cell, it is covered with glial cells. This prevents neurons from contacting each other except at points specialized for signal transmission
Types of Neuroglia
There are six kinds of neuroglia
4 types occur only in the CNS
Oligodendrocytes
Ependymal cells
Microglia
Astrocytes
Oligodendrocytes
(octopus) insulates the nerve fiber from the extracellular fluid (myelin sheath)
Ependymal cells
resemble a cuboidal epithelium lining the internal cavities of the brain and spinal cord.
• produce cerebrospinal fluid (CSF), a liquid that bathes the CNS and fills its internal cavities
•have patches of cilia on their apical surfaces that help to circulate the CSF
Microglia
small macrophages that develop from white blood cells called monocytes
Astrocytes
(starlike) are the most abundant and constitute over 90% of the tissue in some areas of the brain.
Functions:
• form a supportive framework , the blood–brain barrier
• Scar tissue and fill space formerly occupied by damaged neurons (astrocytosis or sclerosis)
Types of Neuroglia
The other two types of glial cells occur only in the PNS:
Schwann cells, or neurilemmocytes
Satellite cells
Schwann cells, or neurilemmocytes
envelop nerve fibers of the PNS
• Produce a myelin sheath similar to the one produced by oligodendrocytes in the CNS
• Assist in the regeneration of damaged fibers
Satellite cells
surround the neurosomas in ganglia of the PNS
• provide electrical insulation around the soma
• Regulate the chemical environment of the neurons
Myelin
insulating layer around a nerve fiber
• It is formed by oligodendrocytes in the CNS and Schwann cells in the PNS
• Its composition is like that of plasma membranes in general (20% protein and 80% lipid)
Myelination
Production of the myelin sheath (it is completed until late adolescence)
Conduction Speed of Nerve Fibers
Depends on two factors:
DIAMETER of the fiber
Signal conduction occurs along the surface of a fiber, not deep within its axoplasm
Large fibers have more surface area and conduct signals more rapidly than small fibers
PRESENCE or absence of myelin
Myelin speeds up signal conduction
The Cerebrum
83% of the brain’s volume
• Consists of a pair of cerebral hemispheres
• Thick folds called gyri (singular, gyrus) separated by shallow grooves called sulci (singular, sulcus)
• A deep median groove, the longitudinal fissure, separates the right and left hemispheres from each other
• At the bottom of this fissure, the hemispheres are connected by a thick bundle of nerve fibers called the corpus callosum
The Cerebrum Lobes
Frontal lobe
Parietal lobe
Occipital lobe
Temporal lobe
The insula
Frontal lobe
voluntary motor functions
motivation
planning
mood
emotion
social judgment
aggression
Parietal lobe
primary site for receiving and interpreting signals of the general senses
Occipital lobe
principal visual center of the brain
Temporal lobe
hearing
smell
learning
some aspects of vision and emotion
insula
small mass of cortex deep to the lateral sulcus, made visible only by retracting or cutting away some of the overlying cerebrum
Cerebellum
Occupies the posterior cranial fossa inferior to the cerebrum, separated from it by the transverse cerebral fissure
It consists of right and left cerebellar hemispheres connected by a narrow bridge called the vermis
Each hemisphere exhibits folds called folia separated by shallow sulci
Its most distinctive neurons→Purkinje cells
The cerebellum is connected to the brainstem by cerebellar peduncles:
- Inferior peduncles connected to the medulla oblongata (spinal input)
- Middle peduncles to the pons (cerebral input)
- Superior peduncles to the midbrain (cerebellar output)
The white matter exhibits a
branching pattern called the arbor vitae
The function of the cerebellum
center for monitoring muscle contractions and aiding in motor coordination
Gray and White Matter
The brain, like the spinal cord, is composed of gray and white matter
Gray matter
the seat of the neurosomas, dendrites, and synapses
• forms a surface layer called the cortex over the cerebrum and cerebellum, and deeper masses called nuclei surrounded by white matter
White matter
lies deep to the cortical gray matter in most of the brain, is composed of bundles of axons, which here connect one part of the brain to another and to the spinal cord
The brain is enveloped in three connective tissue
membranes→the meninges
- Dura mater
- Arachnoid mater
- Pia mater
They protect the brain and provide a structural framework for its arteries and veins
The Dura Mater
Consists of two layers
—an outer periosteal layer equivalent to the periosteum of the cranial bones, and an inner meningeal layer
Dural sinuses
spaces that collect blood that has circulated through the brain
Superior sagittal sinus
under the cranium along the median line
Transverse sinus
which runs horizontally from the rear of the head toward each ear and empty into the internal jugular veins of the neck
The Arachnoid Mater and Pia Mater
The arachnoid mater is a transparent membrane over the brain surface
• A subarachnoid space separates it from the pia below, and in some places, a subdural space separates it from the dura above
The pia mater is a very thin, that closely follows all the contours of the brain, even dipping into the sulci
• It is not usually visible without a microscope
Meningitis
Inflammation of the meninges
Is one of the most serious diseases of infancy and childhood It occurs especially between 3 months and 2 years of age
Causes: a variety of bacteria and viruses that invade the CNS by way of the nose and throat, often following respiratory, throat, or ear infections
Signs and symptoms include: high fever, stiff neck, drowsiness, intense headache, and vomiting
Diagnosed by: spinal tap (lumbar puncture) - examination of the cerebrospinal fluid (CSF) for bacteria and white blood cells
Cerebrospinal Fluid
On the floor or wall of each ventricle is a mass of blood capillaries called a choroid plexus
• Ependyma, a type of neuroglia that resembles a cuboidal epithelium, lines the ventricles and canals and covers the choroid plexuses→ produces cerebrospinal fluid
clear, colorless liquid that fills the ventricles and canals of the CNS and bathes its external surface
CSF production begins with the filtration of blood plasma through the capillaries of the brain
Ventricles (CSF circulation) The brain has 4 internal chambers called ventricles
• The largest are the lateral ventricles, which form an arc in each cerebral hemisphere
• Through a interventricular foramen, each lateral ventricle is connected to the third ventricle, (inferior to the corpus callosum)
• The cerebral aqueduct passes down the core of the midbrain and leads to the fourth ventricle, between the pons and cerebellum
• Caudally, this space narrows and forms a central canal that extends through the medulla oblongata into the spinal cord
Blood Supply
• Because neurons have such a high demand for ATP, and therefore glucose and oxygen, the constancy of blood supply is especially critical to the nervous system
• A 10-second interruption in blood flow can cause loss of consciousness
• an interruption of 1 to 2 minutes can significantly impair neural function
• 4 minutes without blood causes irreversible brain damage
• Damaged brain tissue is essentially irreplaceable, and the brain therefore must be well protected
Brain Barrier System
• The brain is well protected by the blood–brain barrier (BBB), which consists of tight junctions between the endothelial cells that form the capillary walls
• The brain barrier system (BBS) is highly permeable to water, glucose, and lipid-soluble substances such as oxygen, carbon dioxide, alcohol, caffeine, nicotine, and anesthetics
The brainstem
what remains of the brain if the cerebrum and cerebellum are removed
Its major components, from rostral to caudal, are:
• Midbrain
• Pons
• Medulla oblongata
Caudally, the brainstem ends at the foramen magnum of the skull, and the CNS continues below this as the spinal cord