Lab exam 1 Flashcards
what is a lobotomy? describe procedure
use electroconvulsion to make the patient unconscious (later was done on conscious patients). Insert an ice pick up through the eye orbital by tapping with hammer. Pick breaks through the soul into the frontal lobe. Wiggle the pick back and forth to scramble the frontal lobe.
Results: calms emotions, demobilizes the person, lack of social life, child-like uninhibited behavior, basically completely lost themselves
what circumstances allowed lobotomies to gain popularity
There was a large mental illness problem and no solution offered. hospitals were overcrowded and had terrible conditions for mentally ill people. After the war, veterans came back and the problem got even worse. People would accept wild ideas to solve this problem, and lobotomies had somewhat successful results initially, although terrible long term effects. Doctors delivering public criticism wasn’t really a thing at the time so they couldn’t stop it from spreading in popularity. The press was a big fan of the operation because it was a “miracle surgery” and Freeman was happy to make it a spectacle for them.
Who invented lobotomies? name all of the important players in the development
Egas Moniz: won Nobel prize for his operation of altering the frontal lobe to solve mental illness
Walter Jackson Freeman: inspired by Moniz, came up with the idea of frontal lobe surgery that would evolve into the lobotomy
James Watts: worked with Freeman and assisted with the initial surgeries. Left Freeman after seeing his simplified lobotomy where an ice pick is hammered through the eye.
Chemical lobotomies are possible by what drug
Thorazine
define leukemia and the types of leukemia
Leukemia is a blood/bone marrow cancer that causes increased white blood cells
Acute Lymphoblastic leukemia (ALL): rapid increase of immature blood cells, crowding the marrow and stopping production of healthy blood cells. Cancerous change takes place in precursors to lymphocytes, often B cells
Chronic Lymphoblastic leukemia (CLL): excessive build up of mature (abnormal) white blood cells. Cancerous change takes place in precursors to lymphocytes, often B cells (Hairy cell leukemia is a subtype of CLL, uncommon, characterized by abnormal B lymphocytes)
Acute Myelogenous leukemia (AML): rapid increase of immature blood cells, crowding the marrow and stopping production of healthy blood cells. Cancerous change takes place in precursors to red blood cells, other white blood cells, and platelets
Chronic Myelogenous leukemia (CML): excessive build up of mature (abnormal) white blood cells. Cancerous change takes place in precursors to red blood cells, other white blood cells, and platelets
what demographics are most often affected by each type of leukemia
Acute lymphoblastic leukemia (ALL): most common in children. Also some older adults
Chronic lymphoblastic leukemia (CLL): older adults over 55, sometimes younger adults. Never children. two thirds of affected people are men.
Acute myelogenous leukemia (AML): more in adults than children, more in men than women
Chronic myelogenous leukemia (CML): mainly adults, very small number of children
Common symptoms of leukemia
easily bruised, bleed excessively, develop pinprick bleeds called Petechiae, weak immune system, anemia, dyspnea, pallora
how is leukemia diagnosed
count blood cells under microscope and perform bone marrow examination. A high number of white blood cells are apparent under microscope when leukemia is present. A lymph node biopsy may also be helpful to diagnose
Sometimes there is not a high white blood cell count in the bloodstream, this is called aleukemia. The bone marrow still contains cancerous white blood cells but they stay in the marrow so aren’t seen in the blood test.
**The Avier Rod is an indicator of AML
known causes of leukemia
ionizing radiation
viruses like Human T-lymphotropic virus (for adult T cell leukemia)
Benzene and alkylating chemotherapy agents
Tobacco use (for AML in adults)
petrochemicals
hair dyes
maybe high ELF magnetic fields
there is also some genetic predisposition, people with Down syndrome are high risk.
name the types of white blood cells in order from most common to least common
Neutrophils, lymphocytes, monocytes, eosinophils, basophils (never let monkeys eat bananas)
blood cells that are not WBCs are erythrocytes (RBCs) and platelets
Identify what each leukemia type looks like under microscope
ALL: lots of immature lymphocyte precursors with larger nuclei.
CLL: lots of mature appearing lymphocytes, often the blood smear ruptures the lymphocytes and they appear as “smudge cells”
Hairy cell leukemia: lots of B cell lymphocytes that look hairy
AML: lots of immature myeloblasts with prominent nucleoli. Auer rods (eosinophilic rod-like cytoplasmic inclusions) are helpful to identify AML with.
CML: lots of basophils and eosinophils and more immature myeloid cells. Not as many blasts as AML
What did the guy in the vital signs “watermelon” article have? how did they treat?
Chronic myelogenous leukemia. Treated by Gleevec, a drug that inhibits the mutant tyrosine kinase produced in patients which causes the uncontrolled multiplication of white blood cells.
describe the action of a monosynaptic stretch reflex
Tendon is stimulated (like by reflex hammer), sensory spindle detects stimulus and sends input to the spinal cord, information crosses one synapse to a motor neuron that sends output and causes muscle to contract.
describe the action of a polysynaptic reflex
tendon is stimulated, sensory neuron sends signals ALSO to interneurons in the spinal cord which connect and signal other motor neurons, these send output and cause antagonistic muscles (like hamstrings) to relax (extend?) while agonist muscle contracts
describe deep tendon reflexes
DTR’s flex muscles back to normal position. Sensory input from fully contracted muscle is sent to spinal cord, which signals the two groups of muscles via interneurons. One signal tells the contracted muscle (like the quads) to relax and the other signal tells the relaxed muscle (like the hamstrings) to contract. Returning to resting position (in this example the calf is resting)
DTRs oppose stretch reflexes!
