Lab 8 Flashcards

1
Q

5 functional cortex

A

5 Functional types of cortex

  1. Primary sensory and motor
  2. unimodal association
  3. multimodal association
  4. paralimbic
  5. limbic
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2
Q

Primary sensory and primary motor cortex parts (x7)

A
  1. Primary motor=precentral gyrus, frontal lobe
  2. primary sensory=post central gyrus, parietal lobe
  3. primary auditory= superior temporal gyrus, temporal lobe
  4. Primary visual= banks of calacrine fissure, occipital lobe
  5. primary olfactory=piriform olfactory
  6. primary vestibular= posterior deep sylvian fissure where temporal lobe joins insula and parietal lobe
  7. primary gustatory= inferior part of post-central gyrus
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3
Q

Unimodal association area fct?

A

processing ONE type of sensory information

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4
Q

Unimodal association areas (x7)

A
  1. visual association= most of occipital lobe and part of inferior temporal lobe
  2. Auditory associatio= superior temporal gyrus (temp lobe)
  3. Somatosensory association= posterior bank of post-central sulcus (parietal lobe)
  4. vestibular=uncertain, surround primary vestibular, insula
  5. motor-anterior precentral, frontal lobe
  6. gustatory- insula and parts surrounding primary sensory
  7. olfactory- uncertain, paralimbic zones
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5
Q

Multimodal association cortex parts (x5)

A
  1. Prefrontal- mass of cortex in frontal lobe
  2. posterior parietal= inferiro parietal lobule (with supramarginal and angular gyri), areas posterior to association somatosens
  3. Lateral temporal cortex= middle temporal gyrus
  4. Medial parietooccipital gyrus
  5. Fusiform gyrus
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6
Q

Parts of paralimbic cortex (x5)

A

Parts of paralimbic cortex (x5)

  1. Parahippocampal (entorhinal)
  2. cingulate (with anterior/post extensions)
  3. posterior orbitofrontal cortex
  4. temporal lobe
  5. insula
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7
Q

Limbic cortex parts (x2)

A

Limbic cortex parts=

  1. piriform olfactory cortex
  2. Hippocampus
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8
Q

Cortical histology layers

A

Cortical histology layers (outer to inner)

  1. molecular= mostly neuronal processes
  2. External granular layer- input from and output to other cortical areas
  3. External pyramidal= input/output from/to other cortical arease
  4. Internal granular layer- input from thalamus
  5. internal pyramidal= LARGE neurons to striatum, brainstem and spinal cord
  6. to thalamus
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9
Q

With the exception of ____, all info enters cortex via?

A

Olfaction; all other enter via thalamus

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10
Q

Thalamus parts associated with:

  1. Primary visual
  2. Primary auditory
  3. somatosensory
  4. primary motor
  5. Limbic system
  6. prefrontal multimodal
  7. parietal multimodal
  8. Occipitoparietotemporal multimodoal
A

Thalamus parts associated with:

  1. Primary visual: LGN
  2. Primary auditory: MGN
  3. somatosensory: VPM, VPL
  4. primary motor: VA/VL
  5. Limbic system: Anterior nucleus
  6. prefrontal multimodal: MD nucleus
  7. Parietal multimodal: LP
  8. Occipitoparietotemporal multimodal: Pulvinar
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11
Q

Markers for

  1. Retrograde
  2. Anterograde
  3. activation markers
A
  1. Retrograde= HRP (horse radish peroxidase); fluorescent dyes
  2. Anterograde= PHAL-L and radioactive amino acids
  3. activation markers= Fos staining
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12
Q

Left hemisphere associated with?

A

LANGUAGE,

Broca= cannot make language, understand it

Wernicke= make language, doesn’t make sense

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13
Q

Right Hemisphere associated with? Lesion would cause?

A
  • ATTNETION to mostly left, but also right side
  • emotional processing.
  • neglect syndrome (on left, opposite of lesion); mild temporary right neglect
  • (Left hemisphere can ONLY direct attention to right)
    *
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14
Q

Which cerebral artery would cause the most damage if occluded? Sx?

Where is occlusion most likely?

A

MCA- lateral cortex supplied, internal structures

Occlusion= unilateral paralysis, sensory loss, and loss of cognition

ICA origin (right after bifurcation from common carotid)= most common place for ebolus

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15
Q

Blood drained via?

A

Superior and inferior saggital sinus to transverse sinus to internal jugular.

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16
Q

Significance of watershed areas?

A

At greatest risk for hypoxic/ischemic events. ACA/MCA

17
Q
  1. Unimodal association deficit?
  2. Multimodal deficits?
    • prefrontal cortex
    • inferior parietal

*

A
  1. selective perceptual deficit w/o general sensory loss
  2. cognitive/personality defects
    • prefrontal= no strategic thinking, conduct issues, personality, emotional integration
    • inferior parietal =deficit at directing attention to speicifc target
18
Q

Whats different about the limbic cortex?

A

Few and poorly differentiated layers

19
Q

What are the 5 functional divisions again? whats something special about the histology of each one?

A
  1. Primary sensory/motor- motor has large layer V; sensory has large layer IV . Sublamina in some layers
  2. Unimodal association- 6 layers
  3. Multimodal association- 6 layers
  4. paralimbic- core= fewer layers; moving to neocortex, emergence of layer 2 and 4
  5. limbic-low differentiation, large pyramidal neurons
20
Q

Lesion to supramarginal gyrus?

A

Conduction aphasia- disconnection of arcuate fibers that connect Wernicke’s and Broca’s area. Cannot repeat spoken words.

21
Q

Papez Circuit

A

Entorhinal cortex ==perforant pathway==>

hippocampal formation ===fornix==>

Mammillary bodies==mammilothalamic tract==>

Cingulate gyrus==cingulum bundle==> entorhinal cortex

22
Q

Parts of hippocampal formation, layers?

A

3 layers total

  1. Dentate gyrus- has granule layer
  2. Hippocampal gyrus- pyramidal layer
  3. Subiculum
23
Q

Cholinergic projectsion to cortex? Function of Ach?

A
  1. Sinstantia inominota (basal nucleus of meynert)
  2. pedunculopontine nucleus (in brainstem)
  3. Lateral dorsal tegmental nucleus

Ach for REM

24
Q

4 Major functions of the Limbic System

A
  1. Memory and learning
  2. Emotions
  3. linking visceral state to mental state
  4. Perception of pain, smell and touch