Lab 5 Neoplasia Flashcards
Describe the diagnostic features of colon adenocarcinoma cells.
hyperchormatic crowded glands with reduced mucous production due to reduced differentiation (fewer goblet cells)
pilling up of nuclei with increased mitotic activity and variable nuclei size
Contrast pudunculated and sessile neoplastic lesions.
pudunctulated develop with a stalk as they are pulled out into the fecal stream, develop more slowly and less likely to invade rapidly
sessile develop directly in contact with the colonic epithelium, typically more aggressive cells which become a carcinoma much more quickly
Proliferation of stroma in a cancer is due to growth factors produced where?
by neoplastic cells or inflammatory cells that are often attracted by necrosis of lesion
What is a koilocyte?
cell that has been virally infected, significant cellular proteins have been destroyed and cell cannot become malignant
What are the differences between normal endocervical glands and squamous cell carcinoma?
failure of differentiation leads to large darker nuclei that do not follow normal cellular architecture
Are teratomas malignant?
most are made of adult differentiated tissue which very infrequently demonstrate malignant changes
rarely immature teratomas can consist of embryonic or fetal tissues and can show malignant capabilities
Contrast the genetic aberrations that occur in Burkitt lymphoma and follicular lymphoma.
follicular (note many similarly sized germinal centers) that are due to 14/18 translocation causing activation of Bcl2 which causes cells not to die, but instead accumulate in the germinal centers
burkitt lymphoma results from a 14/8 translocation which activates c-myc causing increased transcription and cellular proliferation, so there is gross accumulation of lymphocytes in the lymph node (Starry night)
