Lab 4 Immunity

Question 1

Describe the glomerular changes that occur in Lupus.

Answer 1

wire loop basement membrane as immune complexes stick to the basement membrane (thickening of basement membrane), less space is apparent in the glomerular capsule

fibrosis in blood vessels due to deposition of immune complexes, causes acute necrotizing vasculitis and chronic fibrosis and impaired kiney flow

Question 2

Describe the histological changes in skin under scleroderma.

Answer 2

a type II hypersensitivity there are antibodies raised against topoisomerase

there appears thinning of the epidermis, with dense bands of collagen which abut the epidermis; there is less invagination of the epidermis due to atrophy

Question 3

Antibody deposition in Scleroderma leads to release of factors like ______ and engagement of _________ cells.

Answer 3

TGF-B initiates fibrosis and inhibits metaloproteins that break down collagen, notice the “onion skin” wrapping around vessel due to medial hyperplasia; engagement of CD4+

Question 4

Name the chemoattractant of eosinophils.

Answer 4

IL-5

Question 5

How does development of an aneurysm in Kawasaki disease?

Answer 5

Kawasaki due to viral infection, there is an autoimmune reaction due to cellular mimicry, often effecting coronary artery

immune reaction cross binding can cause inflammation and weaken the vessel walls and cause aneurysm and thrombus.