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Anesthesia Pharm Doses/MAC/Coefficients > LA Lecture 2-3 > Flashcards

LA Lecture 2-3 Flashcards

1
Q

Antiarrhtymic Drug Class for Sodium-channel blockers

A

Class 1

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2
Q

Lidocaine Intraop Dose

Bolus and Infusion

A

1 mg/kg infusion over 1hr

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3
Q

Lidocaine
Amide or Ester
Initial Bolus Dose
Gtt Dose

A

Amide
1-2 mg/kg IV over 2-4 min. (bolus)
1-2 mg/kg/hr (gtt)
Terminated 12-72 hrs

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4
Q

Plasma Lidocaine Concentration Effect
1-5 (mcg/ml)

A

Analgesia

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5
Q

Plasma Lidocaine Concentration Effect
5-10 (mcg/ml)

A

Circum-oral numbness
Tinnitus
Skelatal muscle twitching
Systemic hypotension
Myocardial Depression

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6
Q

Plasma Lidocaine Concentration Effect
10-15 (mcg/ml)

A

Seizures
Unconsciousness

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7
Q

Plasma Lidocaine Concentration Effect
15-25 (mcg/ml)

A

Apnea
Coma

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8
Q

Plasma Lidocaine Concentration Effect
>25 (mcg/ml)

A

CV depression

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9
Q

Name the Esters

A

Procaine
Chloroprocaine
Tetracaine

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10
Q

Procaine
Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH
Fraction Non ionized at 7.6 pH

A

Potency: 1
Onset: Slow
Max single Dose: 500
PK: 8.9
Protein Binding: 6
Fraction Non ionized at 7.4 pH: 3
Fraction Non ionized at 7.6 pH: 5

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11
Q

Chloroprocaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Rapid
Max single Dose: 600
PK: 8.7
Protein Binding: n/a
Fraction Non ionized at 7.4 pH: 5
Fraction Non ionized at 7.6 pH:7

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12
Q

Tetracaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 16
Onset: Slow
Max single Dose: 100
PK: 8.5
Protein Binding: 76
Fraction Non ionized at 7.4 pH: 7
Fraction Non ionized at 7.6 pH: 11

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13
Q

Name the Amides

A

Lidocaine
Prilocaine
Mepivacaine
Bupivacaine
Levobupivacaine
Ropivacaine

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14
Q

Lidocaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 1
Onset: Rapid
Max single Dose: 300
PK: 7.9
Protein Binding: 70
Fraction Non ionized at 7.4 pH:25
Fraction Non ionized at 7.6 pH: 33

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15
Q

Prilocaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 1
Onset: Slow
Max single Dose: 400
PK: 7.9
Protein Binding: 55
Fraction Non ionized at 7.4 pH: 24
Fraction Non ionized at 7.6 pH: 33

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16
Q

Mepivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 1
Onset: Slow
Max single Dose: 300
PK: 7.6
Protein Binding: 77
Fraction Non ionized at 7.4 pH: 39
Fraction Non ionized at 7.6 pH: 50

17
Q

Bupivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Slow
Max single Dose: 175
PK: 8.1
Protein Binding: 95
Fraction Non ionized at 7.4 pH: 17
Fraction Non ionized at 7.6 pH: 24

18
Q

Levobupivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Slow
Max single Dose: 175
PK: 8.1
Protein Binding: >97
Fraction Non ionized at 7.4 pH: 17
Fraction Non ionized at 7.6 pH: 24

19
Q

Ropivacaine
*Potency
Onset
Max single Dose
PK
Protein Binding
Fraction Non ionized at 7.4 pH:
Fraction Non ionized at 7.6 pH: *

A

Potency: 4
Onset: Slow
Max single Dose: 200
PK: 8.1
Protein Binding: 94
Fraction Non ionized at 7.4 pH: 17
Fraction Non ionized at 7.6 pH: N/A

20
Q

Lidocaine
Max infiltration Plain
Max Infiltration w/ Epi

A

300 mgs
500 mgs

21
Q

Procaine Lipid Solubility

A

0.6 (Least Esters)

22
Q

Tetracaine Lipid Solubility

A

80 (Most Esters)

23
Q

Lidocaine Lipid Solubility

24
Q

Prilocaine Lipid Solubility

A

0.9 (Least Amides)

25
Mepivicaine Lipid Solubility
1
26
Bupivacaine Lipid Solubility
28 (Most Amides)

Anesthesia Pharm Doses/MAC/Coefficients (15 decks)

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