Exam 4 Local Anesthetics

Question 1

Lidocaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein b

Answer 1

pK: 7.9
Potency: 1
Lipid Solubility: 2.9
Fraction Nonionized % at pH 7.4: 25
Protein binding: 70

Question 2

Prilocaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein binding

Answer 2

pK: 7.9
Potency: 1
Lipid Solubility: 0.9
Fraction Nonionized % at pH 7.4: 24
Protein binding: 55

Question 3

Mepivacaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein binding

Answer 3

pK: 7.6
Potency: 1
Lipid Solubility: 1
Fraction Nonionized % at pH 7.4: 39
Protein binding: 77

Question 4

Bupivacaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein binding

Answer 4

pK: 8.1
Potency: 4
Lipid Solubility: 28
Fraction Nonionized % at pH 7.4: 17
Protein binding: 95

Question 5

Ropivacaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein binding

Answer 5

pK: 8.1
Potency: 4
Lipid Solubility: –
Fraction Nonionized % at pH 7.4: 17
Protein binding: 94

Question 6

Procaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein binding

Answer 6

pK: 8.9
Potency: 1
Lipid Solubility: 0.6
Fraction Nonionized % at pH 7.4: 3
Protein binding: 6

Question 7

Tetracaine
State the PK, Potency, Lipid Solub., Fraction non ionized, and protein binding

Answer 7

pK: 8.5
Potency: 16
Lipid Solubility: 80
Fraction Nonionized % at pH 7.4: 7
Protein binding: 76

Question 8

Methylene Blue
Treats what?
How much of what local was given?
Dose?

Answer 8

Methemoglobinemia
>600mg of Prilocaine was given
1-2mgs/kg over 5 mins
Do not exceed 8mg/kg

Question 9

Which local has a long duration of action?
What case would it be good for?
What would it not be good for?

Answer 9

Mepivacaine because it does not vasodilate.
Long hip case
OB: do not use; prolonged elimination in fetus

Question 10

Fastest metabolism for Esters

Answer 10

cholroprocaine > procaine > tetracaine

Question 11

Benzocaine Spray delivers how much?

Answer 11

1 brief spray - 200-300mgs

Question 12

Lidocaine Max Dose

Answer 12

300mg
500mg with Epi

Question 13

Mepivacaine Max Dose

Answer 13

400mg
500mg with Epi

Question 14

Bupivacaine Max Dose

Answer 14

175mg
225mg with Epi

Question 15

Tumescent Lidocaine Max with Epi

Answer 15

35-55mg/kg

Question 16

Regional Anesthesia Lidocaine with Epi

Answer 16

7mg/kg