L97 - Psychosis and Antipsychotics

Question 1

What class of drugs are these?

1. Chlorpromazine (Thorazine)
2. Thioridazine (Mellaril)
3. Fluphenazine (Permitil, Prolixin)
   4. Perphenazine (trilafon)

Answer 1

• Phenothiazines:

Question 2

what class of drugs are these? 
 Thiothixene (Navane)

Answer 2

• Thioxanthenes

Question 3

What class of drug is 
Haloperidol (haldol)?

Answer 3

• Butyrophenones

Question 4

What class of drugs are these?

1. Aripiprazole (Abilify)
2. Asenapine (Saphris)
3. Clozapine (Clozaril)
4. Lurasidone (Latuda)
5. Olanzpine (Zyprexa)
6. Paliperidone (Invega)
7. Quetiapine (Seroquel)
8. Risperidone (Risperdal)
9. Ziprasidone (Geodon)

Answer 4

• Atypicals

Question 5

pulled from the market after deaths due to agranulocytosis
Eventually approved in the US in 1989 for schizophrenia/ schizoaffective disorder
Also approved to specifically treat suicidal behaviors in schizophrenia
Only antipsychotic shown to be more efficacious than others – However, it is only used for treatment resistant schizophrenia….

Answer 5

Clozapine

Question 6

Side Effects of Particular Concern with Clozapine

Answer 6

Agranulocytosis : WBC and ANC monitoring required to dispense
Seizures at high doses
Constipation, Paralytic ileus
Sialorrhea
Myocarditis
Orthostatic hypotension and tachycardia
Monitor before each dose when starting, slowly titrate

Question 7

1st antipsychotic
• In the presence of MAO inhibition, this drug or haloperidol increased catecholamine metabolites
• Mechanism of this effect via catecholamine (DA) receptor blockade
• Chemical, typical/first generation
• Low potency

Answer 7

Chlorpromazine

Question 8

chemical, typical/first generation, high potency (2 drugs)

Answer 8

Fluphenazine and haloperidol