L 86 - metastatic disease of the skeleton Flashcards
1
Q
Which drug binds to bone and is taken up by osteoclasts?
A
bisphosphonates
2
Q
Degradation-resistant - dec hypercalcemia
Induce osteoclast apoptosis, prevent resorption
A
bisphosphonates
3
Q
SE of bisphosphonates (2)?
A
osteonecrosis of the jaw
atypical femur fractures
4
Q
Human monoclonal antibody (“mab”)
Directly binds RANKL – Similar to OPG
Blocks osteoclast maturation
A
denosumab
5
Q
T/F: Metastatic disease to bone is common in patients with carcinoma.
A
T
6
Q
Bone destruction is caused by osteoclast stimulation in the _____ pathway.
A
RANK
7
Q
What is important to rule out prior to treatment of skeletal disease?
A
primary sarcoma
8
Q
What is the focus of surgery in metastatic disease of the skeleton?
A
functional optimization
