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FHB GI Material - Richie > L7 - Small Intestinal Phase > Flashcards

L7 - Small Intestinal Phase Flashcards

1
Q

Presence of fat, H+, and hyper osmotic content in duodenum promotes…

A

inhibition (slowing) of gastric emptying via 1. CCK 2. CNX efferents decrease motility, contract pylorus 3. H+ receptor mediated Myenteric plexus relax gastric smooth muscle

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2
Q

Which of the following make HCO3-? A. Exocrine pancreas B. Biliary ductules C. Duodenal epithelial cells D. All of the above

A

D. all of the above

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3
Q

The majority of pancreatic volume is exocrine, or endocrine?

A

Exocrine 90%

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4
Q

Which of the following cells of exocrine pancreas secrete enzymes? A. Acinar cells B. Centroacinar cells C. Ductal cells D. B and C

A

A. Acinar cells. Centroacinar cells and ductal cells secrete the aqueous component.

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5
Q

Pancreatic exocrine acinar fluid production is regulated by

A

CCK

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6
Q

Pancreatic exocrine ductal fluid production is regulated by

A

Secretin

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7
Q

What triggers secretin release from S-cells (in duodenum), to promote ductal bicarbonate secretion in the pancreatic TUBULAR cells?

A

low pH

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8
Q

Secretin-mediated cAMP directly stimulates which transporter, in pancreatic ductal cells? A. NHE-1 B. NBC-1 C. Bicarb/Cl- antiporter D. CFTR

A

D. CFTR

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9
Q

CFTR-mediated secretion of Cl- powers the secretion of

A

HCO3- via the Cl-/HCO3- antiporter on the luminal ductal cell of pancreas. This antiporter is coupled with CFTR.

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10
Q

CFTR “couples with” what transporter, on the luminal side of pancreatic ductal cells?

A

Cl-/HCO3- antiporter

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11
Q

Name 2 sources of secreted HCO3-, via the Cl-/HCO3- antiporter on luminal side of pancreatic ductal cell.

A

From within: Carbonic anhydrase From without: Na/Bicarb symporter (NBC-1)

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12
Q

In Cystic fibrosis A. Secretin release by I-cells is impaired B. CFTR is impaired C. Acinar cells don’t release enzymes D. Bicarb secretion is intact

A

B. CFTR is impaired

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13
Q

CCK is released from what cells?

A

I-cells in duodenum

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14
Q

I-cells can DIRECTLY interact with which of the following, to promote secretion of CCK? A. Fatty acids & Proteins B. CCK releasing peptide C. Monitor peptide D. All of the above

A

D. All of the above

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15
Q

What stimulates pancreatic release of monitor peptide?

A

CN X Enteric nervous system

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16
Q

What digests monitor peptide and CCK-RP?

A

Trypsin

17
Q

What competes with monitor peptide and CCK-RP, for Trypsin-digestion?

A

Protein rich meal. In effect, dietary proteins free up CCK-RP and monitor peptide, which are now available to promote release of CCK from I-cells, so that CCK can stimulate release of digestive enzymes from pancreatic acinar cells for that meal. When you’re NOT eating, you don’t need CCK, and trypsin is free to digest CCK-RP and monitor peptide.

18
Q

Which does not promote intracellular Ca++ levels in pancreatic acinar cells? A. VIP B. GRP C. CCK D. GRP

A

A. VIP

19
Q

What hormone relaxes the Sphincter of Oddi?

A

CCK

20
Q

What hormone promotes contraction of gallbladder?

A

CCK

21
Q

What is the major constituent of bile?

A

Bile acid (65%)

22
Q

How are conjugated bile acids re-absorbe into enterohepatic circulation?

A

ASBT (apical Na+ dependent bile acide transporter) in terminal ileum

23
Q

If bile acid is conjugated, then

A

it cannot passively cross the intestinal epithelial lining

24
Q

What type of contraction occurs in the esophagus, pharynx, gastric antrum, small/large intestine?

A

Peristaltic

25
Q

What type of contraction occurs in small and large intestines

A

segmentation

26
Q

During peristaltic movement, which relaxes - orad or caudad?

A

Caudad is ahead of the bolus, so relaxes

27
Q

What promotes caudad relaxation during peristalsis?

A

VIP and NO

28
Q

What promotes orad contraction during peristalsis?

A

ACh and Substance P

29
Q

During fasting conditions, what hormone produces migrating motor complexes MMC?

A

motilin

30
Q

What secretes mucus and bicarb in small intestine?

A. Brunner glands

B. Lieberkuhn glands

C. Paneth cells

A

A. Brunner glands

31
Q

What gland secretes peptidases and carb digestors?

A

Lieberkuhn glands

32
Q

What cells reside at the bottom of villi and secrete antimicrobial peptides and enzymes?

A

Paneth cells

FHB GI Material - Richie (8 decks)

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