L7 - Parkinsonism

Question 0

Parkinson’s occurrence rates

Answer 0

• prevalence: 150-200/100 000

- incidence: 16-19/100 000 per year

Question 1

Alpha-synuclein:

Answer 1

• expressed in cortical neurons
• involved in presynaptic vesicle transport and synaptic plasticity
• aggregation leads to Lewy-body formation

Question 2

Main feature of Parkinson’s

Answer 2

• degeneration of the nigro-striatal system

Question 3

The most common form of dementia after AD:

Answer 3

DLB - dementia with Lewy bodies

Question 4

Features of MSA

Answer 4

• vegetative function impairment/parkinsonism/cerebellar
• probably not hereditary
• hard to diagnose
• incidence ca. 3/100 000 per year
• glial cytoplasmic inclusions - Papp-Lantos bodies
• pathology: primarily oligodendroglial

Question 5

Progressive supranuclear paralysis (PSP)

Answer 5

• incidence: 1/1 Mil.; prevalence 3/100 000
• symmetrical axial rigidity; eye-movement impairment
  Pathology:
• depigmentation of SN

Question 6

CBD - corticobasal degeneration

Answer 6

• no known incidence
  Clinical:
• progressive asymmetric apraxia, rigidity & dystonia
  Pathology:
• increase in hyperphosphorylated tau (4R) in striatum
• microscopic tangles as in PSP bloated neurons
• astrocytic plaques