L4 - Diagnosing AD before dementia

Question 0

New research criteria for AD diagnosis

Answer 0

• episodic memory impairment + 1 or more of the following:
• medial temporal lobe atrophy (MRI)
• abnormal CSG biomarkers (abeta low, tau high, p-tau high)
• abnormal glucose metabolism (FDG PET) or evidence of amyloid (PIB PET)
• autosomal dominant mutation in immediate family

Question 1

Worldwide dementia prevalence in 2010

Answer 1

35.6 mil; 7.7 mil new cases each year

Question 2

A-beta & Tau & pTau in CSF as diagnostic biomarkers:

Answer 2

• Combination of a-beta 42 & tau (but not pTau) in CSF has 93.5% sensitivity and 82.7% specificity

Question 3

[18F]FDG in AD

Answer 3

• FDG - fluordeoxyglucose

- scans show parieto-temporal and posterior cingulate glucose hypometabolism in AD