L7

Question 1

Meyer-Overton rule

Answer 1

Predicts ‘penetration of drugs/anaesthetics’

Question 2

What can penetrate the lipid bilayer?

Answer 2

Hydrophobic molecules –> High P (lipids & gases)
Small, uncharged polar –> modest P (H2O)
Large, uncharged polar –> LOW glucose & amino acids
IONS –> NONE

Question 3

Cocaine

Answer 3

weak base

Question 4

What is membrane solubility proportional to?

Answer 4

oil

Question 5

biological membrane permeability- when do they become permable?

Answer 5

simple diffusion = linear
protein mediate = curve that plateaus
ion channels become permeable at >160mM

Question 6

integral membrane proteins

Answer 6

amino acids adjacent to lipid bilayer = lipophilic
hydrophilic pore region lined with charged amino acid –> route of permeation!

Question 7

ion pumps

Answer 7

one or more substrate transported (at least one against gradient)
pumps have enzymatic activity (ATPase) to hydrolyse ATP to release energy for ion transport (primary AT)

Question 8

Solute carriers

Answer 8

one or more substrate transported (at least one DOWN gradient)
V diverse, >400 genes in 66 carriers. 2nd most diverse group

Question 9

what do SLC’s use

Answer 9

1. facilitated diffusion
2. Co-transporters/symporters
3. Exchangers/antiport

Question 10

What drugs in the brian target SLCs?

Answer 10

Amphetamines and SSRI’s