L6 - principles of drug action

Question 1

what do local anaesthetics do to neurones

Answer 1

inhibit nerve conduction by blocking sodium channels

Question 2

what is the difference between the position of the ganglia in sympathetic and parasympathetic nerves

Answer 2

the ganglion in parasympathetic nerves is closer to the target tissue

Question 3

what region of the spinal chord do sympathetic nerves emanate from

Answer 3

thoracolumbar segments (middle)of the spinal chord

Question 4

where are the ganglia of the sympathetic nerves

Answer 4

close to the spinal chord in the paravertebral chain

Question 5

what region of the spinal chord do parasympathetic nerves emanate from

Answer 5

craniosacral segments
(cranial and sacral)

Question 6

where are the ganglia of the parasympathetic nervous system

Answer 6

close to or inside target tissues

Question 7

what converts precursor into neurotransmitter

Answer 7

enzyme cascade

Question 8

what inhibits the uptake of the precursor for acetylcholine

Answer 8

hemicholinium

Question 9

what inhibits the enzyme cascade that creates noradrenaline

Answer 9

alphamethylparatyrosine (AMPT)

Question 10

what inhibits the vesicle storage of noradrenaline

Answer 10

reserpine

Question 11

what inhibits the release of noradrenaline

Answer 11

guanethidine

Question 12

what inhibits calcium influx

Answer 12

conotoxin

Question 13

what inhibits acetylcholine visible fusion during exocytosis

Answer 13

botulinum

Question 14

effect of benzodiazepine tranquillisers

Answer 14

bind to the GABA receptor/cl ion channel complex to enhance channel opening and potentiate inhibitory effects of GABA