L5 Protein Structure

Question 1

What is conformational change?

Answer 1

Many proteins change their three dimensional shape on binding to a small ligand which may be driven by substrate binding or phosphorylation

Question 2

When a ligand binds to a protein, can it be a weak or a strong binding?

Answer 2

Binding can be tight or weak, but usually very specific

Question 3

What are protein families?

Answer 3

A protein family consists of a number of members, each having a closely related amino acid sequence and three dimensional structure, but with different functions

Question 4

What is post translational modification (PTM)?

Answer 4

They are covalent modifications that occur to a protein after its translation from mRNA.

Question 5

Give me common types of PTMs

Answer 5

Phosphorylation - addition of a phosphate group to amino acids like serine, threonine or tyrosine

Glycosylation - attachment of carbohydrate molecules to amino acids - serine/threonine

Question 6

What do the Lewis structures show?

Answer 6

Shows the location of the electrons in bonds in a molecule and lone pairs around the atoms in a molecule