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MCN II > L5 - Ion Channels and GPCRs > Flashcards

L5 - Ion Channels and GPCRs Flashcards

1
Q

What are the three mechanisms of ion channel function?

A

Conformational change in 1 region
General structure change
Blocking particle

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2
Q

What’s a Cys-loop?

A

On ligand gated ion channels, it is a bridge near the N-term that forms a disulphide bond

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3
Q

What is a connexon?

A

A hemi channel, 2 of which make up a gap junction

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4
Q

What do all voltage gated cation channels have in common?

A

They have homologous alpha subunit domains including a p-loop between the 5th and 6th TM domains.

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5
Q

Describe the structure of a bacterial K channel

A

2 alpha helices form the gates
Glycine residues in the middle act as a hinge
S4 section is believed to be the voltage sensor
4 subunits all with 6 TM domains

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6
Q

How is a bacterial K channel selective?

A

In order for an ion to pass through the channel it must remove it’s water shell, this is energetically unfavourable. In order for potassium to do this it is stablized by oxygen atoms in the selectivity filter.

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7
Q

What is the vertebrate ClC family?

A

Chloride channels and transporters composed of double channeled barrels with 2 identical pores

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8
Q

Describe the 3 conformational model of VGSCs

A

There are three conformations for VGSC. The first is the closed state, then upon depolarisation the activation gate opens entering the open state, after sustained depolarisation the channel’s inactivation gate closes rendering the channel inactivated. It will only return to the closed state after a period of repolarisation.

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9
Q

What diseases could be caused by Ca channel mutations?

A

Familial hemiplegic migraine (FHM)
Familial episodic ataxia (EA2)
Congenital stationary night blindness (CSND)
Paralysis

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10
Q

What diseases could be caused by Na channel mutations?

A

GEFs
Myotonia
Paralysis

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11
Q

What diseases could be caused by K channel mutations?

A

EA1

BFNC

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12
Q

What disease could be caused by chloride channel mutations?

A

Myotonia

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13
Q

What are the nociceptive pain receptors for heat?

A

TRPV1, TRPV2, TRPV3, TREK-1

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14
Q

What are the nociceptive pain receptors for acid?

A

TRPV1, ASIC, DRASIC

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15
Q

What are the nociceptive pain receptors for pressure pain?

A

MDEg, DRASIC, TREK-1

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16
Q

What is the nociceptive receptor for cold?

A

TRPM8

17
Q

Outline the molecular mechanisms of exocytosis during NT release

A
  1. Vesicle Docks
  2. SNARE complexes form to pull the membranes together
  3. Entering Ca binds to synaptotagmin
  4. Ca bound synaptotagmin catalyzes membrane fusion by binding it to SNAREs and the pm
18
Q

What toxin cleaves SNARE proteins?

A

Clostridial toxins

MCN II (10 decks)

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