L4 | Urine Acidification

Question 1

What are the drugs that cause the urine to be acidified?

Answer 1

1. Calcium Chloride (cranberry juice)
2. Ammonium Chloride
3. Arginine-hydrochloride
4. Lysine-dihydrochloride
5. Vitamin C

Question 2

What are their indications?

Answer 2

1. Increase the excretion of certain acidic drugs that cause toxicity like amphetamine, ephedrine, methadone, quinine, phencyclidine
2. To prevent calcium-phosphate renal stone formation
3. Increase the efficacy of certain drugs like penicillins, tetracyclines, Nitrofurantoin, clindamycin and lincomycin.
4. To test for renal tubular acidosis
5. To promote antimicrobial action of methamine, at pH lower than 5.5, methenamine releases formaldehyde which has antibacterial activity.