L4 | Abnormal Micturition

Question 1

What are the drugs that are used in the treatment of urinary frequency, urgency and incontinence?

Answer 1

1. Antimuscaranic drugs: oxybutynine, flavoxate, propiverine, propanthodine, tolterodine and trospium
   (The inhibit the action of the detrusor muscle which increases the capacity of the UB)
2. Tricyclic antidepressants: imipramine, amitriptyline, nortriptyline
3. Estrogen; either applied directly to the vagina or taken by mouth

Question 2

what are the drugs that are used to treat hypotonic bladder and urine retention due to UML?

Answer 2

1. Parasympathomimetics:
   A. Choline esters: bethanechol, carbachol
   B. Anticholinesterases: distigmine

(They stimulate the detruser muscle when the bladder is hypotonic)

2. Intermittent catheterization is also needed when the hypotonia is chronic