L4. Protein Synthesis Inhibitors Flashcards
- cycline
Tetracyclines
BS, Bind to 30S
Minocycline, doxycycline
Tetracylines that cross BBB
“MINute DOCuments CYCLE easily into brain”
Tigecycline
BS, Tetracycline to treat VRE, MRSA and ESBL
Last resort drug!
Tetracycline SE
Food interactions (milk) photosensitivity vertigo GI issue teeth hypoplasia
CI: preg woman and children
Resistance: most common efflux pump
(Resistance to one doesn’t confer resistance to all)
Chloramphenicol
BS, Bind to 50S
For life threatening - last resort infections
(Inhibit peptidyl transferase rxn)
Goes to CSF
SE: gray baby syndrome
Needs glucuronide for metabolism (in babies its less so toxic drug for them)
- mycin
amino-glycosides
ES, Binds 30S
(Assembly of ribosomal apparatus/ misread genetic code)
Amikacin
Aminoglycoside taken orally
Severe nephrotoxicity if not
What’s so special about aminoglycosides?
Only bactericidal protein synthesis inhibitor
Aminoglycosides SE
Ototoxicity, nephrotoxicity
Can inhibit CYP
Aminoglycosides are —— based
Concentration based
- thromycin
Macrolides and ketolides
EX, bind 50S (irreversibly)
Erythromycin
- Use when allergic to penicillin
2. Given after iliac surgery (act on motilin)
Clathromycin
Used in triple therapy against H. Pylori
Amoxicillin, clathromycin and PPI
Azithromycin
Used for resp pathogens
Doesn’t inhibit CYP
Telithromycin
Hepatotoxic!
No longer used in US
Macrolides and ketolides SE
Gastric distress and motility
QT elongation
Clindamycin
NS, bind to 50S
Treats gram positive (including MRSA)
SE: C. Diff
C diff treated with
Vancomycin
- zolid
Oxazolidinones
NS, bind 50S
Gram positive
Linezolid
NS, Oxazolidinone
Treats VRE
Oxazolidinones
NS, bind 50S subunit
Used for gram positive (mainly for drug resistant gram positives - MRSA and VRE)
Have non selective monoamine oxidase
SE: Serotonin Syndrome, GI issues
Whats so special about tetracycline resistance?
Resistance to one doesnt confer resistance to all
