L2. Cell Wall Synthesis Inhibitors Pt 1

Question 1

Clavulanic acid

Answer 1

Beta lactamase inhibitor

Also - bactam

Question 2

• bactam

Answer 2

Beta lactamase inhibitors

Question 3

Resistance to beta lactam (and other anti biotics) factors?

Answer 3

1. Enzyme against drug (ex beta lactamase)
2. Altered target (ex altered PBP)
3. Dec permeability (inc efflux or dec perm)

Question 4

• cillin

Answer 4

Penicillin drugs

Question 5

Penicillin G

Answer 5

BS, Doc for Syphilis

Caused by treponema

Question 6

Penicillin V

Answer 6

BS, Similar spectrum as Pen G

Oral/ limited absorption

Question 7

Amoxicillin

Answer 7

ES, Prevents bacterial endocarditis

Question 8

Ampicillin

Answer 8

ES, Doc for for Listeriosis

Together with Pen G

(Caused by listeria)

Question 9

Piperacillin

Answer 9

NS, Treats pseudomonas

Question 10

Methicllin

Answer 10

NS, Treats MSSA

Penicilinase resistant

SE: interstitial nephritis (not used in US)

Other examples:
Diclo, naf and oxacillin

Question 12

Penicillin drugs SE

Answer 12

Allergies, Diarrhea
Neurotox, hematox

Jarisch Herxheimer
(Host immune response to antigens released by killed organisms - treatment of syphilis)

Question 13

Jarisch Herxheimer

Answer 13

Host immune response to antigens released by killed organisms - trepenoma (syphilis)

Can treat with NSAIDs

Question 14

Penicillin and placental passing

Answer 14

Can pass but no bad effects

Question 15

Only beta lactam metabolized in liver?

Answer 15

Nafcillin, oxacillin