L3. Cell Wall Synthesis Inhibitors pt 2 Flashcards
Cef -
Cephalosporins
More resistant to beta lactamases than penicillins
Change in cephalosporin drugs
1st to adv gen
Dec gram positive
Inc gram negative
Ext to broad
Note: adv gen had improved MSSA, MRSA activity
CeftriAXone, cefotAXamine
AXcess to CSF
Cross BBB
Ceftolozane, Ceftazidime
+ bactams
Treat ESBLs
Cephalosporin SE
Can cause c diff
Allergy to Pen =
Allergy to ceph
Use erythromycin!
Aztreonam
NS, monobactam
gram -ve
Pseudomonas!
low cross reactivity
SE: phlebitis (IV, IM)
- penem
Carbapenem
BS, DOC for ESBL!
Doripenem
More potent against Pseudomonas
Erthapenem
Narrower spec of activity
Imipenem
Short half life
(W/o Cilastatin)
SE: may cause seizures!
Cilastatin
Protect against renal DHP
Increase half life of imipenem
Imipenem + cilastatin
Combination used to extend half-life of imipenem
Protect against renal DHP!
SE: N and V, diarrhea
ESBL
Extended spectrum beta lactamase
DOC carbapenem!
Produced by: gram negative bacteria
Resitant to: Pen, cef, monobactam
Note: certain cef + lactam combinations can work against ESBL!
Vancomycin
NS/ BS -> gram +ve, anaerobic and others
Doc for MRSA!
Hugs PG precursor
Doc for c.diff!
Resistance: alteration to PG precursor
SE: Red Man Syndrome
(Parenteral administration)
VRE
Vancomycin resistant Enterococcus
Emerged in Enterococcus faecium infections
Red Man Syndrome
Vancomycin SE if given parenterally
FLUSHING, erythema and pruritus
How is vancomycin given for MRSA?
IV
How is vancomycin given for C diff?
Orally
