L3. Cell Wall Synthesis Inhibitors pt 2

Question 1

Cef -

Answer 1

Cephalosporins

More resistant to beta lactamases than penicillins

Question 2

Change in cephalosporin drugs

Answer 2

1st to adv gen

Dec gram positive
Inc gram negative
Ext to broad

Note: adv gen had improved MSSA, MRSA activity

Question 3

CeftriAXone, cefotAXamine

Answer 3

AXcess to CSF

Cross BBB

Question 4

Ceftolozane, Ceftazidime

+ bactams

Answer 4

Treat ESBLs

Question 5

Cephalosporin SE

Answer 5

Can cause c diff

Question 6

Allergy to Pen =

Answer 6

Allergy to ceph

Use erythromycin!

Question 7

Aztreonam

Answer 7

NS, monobactam

gram -ve
Pseudomonas!

low cross reactivity

SE: phlebitis (IV, IM)

Question 8

• penem

Answer 8

Carbapenem

BS, DOC for ESBL!

Question 9

Doripenem

Answer 9

More potent against Pseudomonas

Question 10

Erthapenem

Answer 10

Narrower spec of activity

Question 11

Imipenem

Answer 11

Short half life

(W/o Cilastatin)

SE: may cause seizures!

Question 12

Cilastatin

Answer 12

Protect against renal DHP

Increase half life of imipenem

Question 13

Imipenem + cilastatin

Answer 13

Combination used to extend half-life of imipenem

Protect against renal DHP!

SE: N and V, diarrhea

Question 14

ESBL

Answer 14

Extended spectrum beta lactamase

DOC carbapenem!

Produced by: gram negative bacteria
Resitant to: Pen, cef, monobactam

Note: certain cef + lactam combinations can work against ESBL!

Question 15

Vancomycin

Answer 15

NS/ BS -> gram +ve, anaerobic and others

Doc for MRSA!
Hugs PG precursor

Doc for c.diff!

Resistance: alteration to PG precursor

SE: Red Man Syndrome
(Parenteral administration)

Question 16

VRE

Answer 16

Vancomycin resistant Enterococcus

Emerged in Enterococcus faecium infections

Question 17

Red Man Syndrome

Answer 17

Vancomycin SE if given parenterally

FLUSHING, erythema and pruritus

Question 18

How is vancomycin given for MRSA?

Answer 18

IV

Question 19

How is vancomycin given for C diff?

Answer 19

Orally