L4 Blood Flashcards
how much of TBW is ECF and ICF
ECF= 1/3
How to measure ECF
TBW= 60,50% of weight
then ECF= 1/3 of TBW
Types of ECF
IF, plasma, lymph
how to measure IF and plasma
IF=4/5 of ECF
plasma= 1/5 ECF
Measuring blood content
8% of TBW
Functions of plasma
- transport
2. plasma protein functions (i.e. coll osmotic pressure)
typical blood volume
5l
typical PCV and define
PCV= packed cell volume, proportion of cells in blood,
= 0.42 . 0.45
where are cells of the blood produced
haemotopoietic stem cells in bone marrow
3 types of blood cells
erythrocytes
leukocytes
plateltets
how does RBC transport O
o binds to haemoglobin in RBC
How does RBC transport CO2
co binds non selectively to proteins + so binds to heamo
> in RBC carbonic anhydrase catalyses carbomino compounds
components of haemoglobin
4 subunits, each containing:
- polypeptide chain (CO binds)
- haem unit (w/Fe molecule where oxygen binds)
4 binding sites= 4 o
explain regulation of RBC production
dec O2 delivery to tissues > stimulates kidneys to secrete erthyopotein > inc erythrocyte prod in bone marrow > inc o2 carrying capacity
name the leukocytes
granulocytes - neutrophils (60%) - eosinophils (3%) - basophils (1%) lymphocytes (30%) mono (5%)
