L14 Control of Ventilation

Question 1

respiratory centres in brain stem

Answer 1

Pons RC

• Apneustic Area
• Pneumotaxic

Medulla RC

• DRG (dorsal resp group
• VRG (ventral resp group

Pre- Botzinger complex-

Question 2

Explain what stimulates ramp signal

Answer 2

• Action potential in PBC stimulate DRG to activate : inspiratory ramp signal

Question 3

what does ramp signal allow

Answer 3

• Gradual increase in lung volume

* Control rate of ventilation

Question 4

what does the pneumotaxic + apneutic areas do

Answer 4

P= inhibitory signals to DRG= limits inspiratory ramp signal 
A= •	Stimulatory signals to inspiratory area to prolong inspiration

Question 5

what does the ventral respiratory group so

Answer 5

forced

• Contribute to expiration and inspiration (has both neurons)

Question 6

how does central chemo receptors pick up H changes

Answer 6

• H in blood Cannot cross blood brain barrier
• But CO2 can // crosses barrier, combines with water= carbonic acid = HH inc > CC receptors > inc respiratory drive > vent inc

Question 7

when are peripheral chemo receptors activated

Answer 7

Needs to drop substantially before stimulation of peripheral

Question 8

steps of neg feedback of ventialtion

Answer 8

changes to PCO2, H O > chemo pick up > send to inspiratory group > hyperventilating > decrease CO2

Question 9

2 voluntary controls of breathing

Answer 9

Hering-Breuer Inflation Reflex
= lung inflate= stretch = inhibit

Irritant Receptor Reflex
= irritation = excitatory responses