L.4 Flashcards
What is mitochondria
Double membrane organelle and the powerhouse
Mitochondria has independent?
Genom
Most of the mit genome is
Transcribed ( 93%)
How many genes in mitochondria
37 genes
……… of the genes are ……..
24 , Encoded non mRNA
……… of the gene are ………
13 , transcribed proteins
Mention the 24 gene ( encoded non mRNA
22 for tRNA
1 for 23S rRNA
1 for 16S rRNA
Mention the 13 transcribed genes
7 NADH dehydrogenase, 3 cytochrome C ( COX ) , 2 ATPase , 1 cytochrome B
Reactive oxygen species (ROS ) generated during which process
ATP synthesis
Why O2 consumption must correspond with ATP synthesis
To neutralize ROS
If O2 consumption not correspond with ATP synthesis what will happen
Accumulation of ROS
Accumulation of ROS happen during what
Mit disease and fever
Most mit proteins encoded from what
Nuclear genom
Why mit disorder related to nuclear DNA
Because most of the mitochondrial proteins come from nucleus
How many genes required for ATP synthesis
90 genes
Mit DNA is only inherited from ?
Mothers
Why does the mitochondrial DNA only inherited from the mother
Because fertilized oocyte will degrade the mitDNA of the sperm
What is the region in the mitochondria that differe from one person to another
Control region
What makes the variation in the mitochondria
Mutations