L.3

Question 1

Chr 19 produce which protein

Answer 1

Fucosyltransferase

Question 2

ABO group at which chromosome

Answer 2

Chromosome 9

Question 3

Chromosome 9 produce which protein

Answer 3

Glycosytransferase

Question 4

Which blood type is dominant

Answer 4

A. B

Question 5

Which blood type is recessive

Answer 5

O

Question 6

Alpha gluon in which chromosome

Answer 6

16

Question 7

Beta , gamma, delta glutinous at which Chr

Answer 7

11

Question 8

Gamma glubin appears at which time

Answer 8

Before birth and reduce after birth

Question 9

Adult hemoglobin is ?

Answer 9

2alpha , 2 beta

Question 10

Foetal hemoglobin is

Answer 10

2 alpha , 2 gamma

Question 11

A2 hemoglobin is

Answer 11

2 alpha , 2 delta

Question 12

The free hemoglobin is execreted by

Answer 12

Kidney

Question 13

When you exceed the limit solubility what happen

Answer 13

Polymerisation and precipitation
Distortion of RBC lead to RBC lysis

Question 14

How can we regulate the synthesis of hemoglobin

Answer 14

Protease break down alpha chain

Question 15

Hb gene expression is regulated by ?

Answer 15

Restructuring chromatin

Question 16

What is haemoglobinopathies ? And give example

Answer 16

Normal quantities but abnormal sequence ( sickle cell anemia )

Question 17

What is thalassemia

Answer 17

Normal sequence but different quantities

Question 18

Sickle cell anemia effect which gene

Answer 18

Beta globin gene

Question 19

In sickle cell anemia under low O2 tension what happen

Answer 19

Polymerisation, distortions of RBC shape lead to obstruction of small vessels and haemolysis

Question 20

In sickle cell anemia glutamic acid become

Answer 20

Valine

Question 21

Thalassemia result in

Answer 21

Not enough Hb or abnormal accumulation of globin

Question 22

How many beta globin

Answer 22

Two ( one on each 11 Chr )

Question 23

What are the types of beta thalassemia

Answer 23

Minor major

Question 24

How many alpha globin

Answer 24

4 ( 2 on each 16 Chr )

Question 25

What are the types of alpha thalassemia .

Answer 25

Silent carrier , alpha thalassemia traits , HbH disease , major

Question 26

Which types are clinically asymptomatic

Answer 26

Silent Carrie and alpha thalassemia traits

Question 27

HbH disease result in what

Answer 27

Production of HbH ( 4 beta globin )

Question 28

Major alpha thalassemia result in ?

Answer 28

HbBart ( 4 gamma globin )

Question 29

HbBart result in

Answer 29

No oxygen is releasing into tissue fetus dies

Question 30

DNA transcription result in

Answer 30

Pre mRNA

Question 31

DNA slicing result in

Answer 31

mRNA

Question 32

DNA translation

Answer 32

Peptide

Question 33

DNA post translation

Answer 33

Proteins

Question 34

What is mutation

Answer 34

Permanent heritable change in nucleotide of gene or chromosome

Question 35

Mutations described in terms of change in ?

Answer 35

Genomic DNA , DNA coding , protein

Question 36

What are the classification of mutation

Answer 36

Deletion , insertion , substitution, frame shift , dynamic mutation

Question 37

3 functional consequences of mutation mention them ?

Answer 37

Loss of function , gain of function , silent mutation

Question 38

See the table lecture 3