L32- Hypothalamic and Pituitary Hormones (adrenocorticotrophs)

Question 1

ACTH analogs

Answer 1

corticotropin

cosyntropin

Question 2

why do ACTH analogs have limited utility as therapeutic agents

Answer 2

less predictable and less convenient than corticosteroid therapy

Question 3

ACTH and its analogs act on (1) receptor, a (2) type of receptor on (3) cells. (4) is the cellular change induced, and (5) is the overall change and goal of ACTH.

Answer 3

1- MC2R
2- Gs
3- adrenal cortex
4- inc cAMP
5- secrete glucocorticoids, androgen precursors + little mineralocorticoids

Question 4

ACTH analogs:

• Dx use
• Tx use

Answer 4

Dx: differentiating Addison’s disease / primary adrenal insufficiency and inadequate ACTH secretion / secondary adrenal insufficiency

Tx: infantile spasm (West Syndrome- seizure disorder possibly due to CRH)

Question 5

ACTH analogs AEs are similar to…..

Answer 5

glucocorticoids: immuno-suppression is main concern