L24 - Introduction to Leukaemia Flashcards
Define Leukaemia?
malignant disorders of haematopoietic stem cells characteristically associated with an increase of white blood cells in bone marrow or/and peripheral blood.
What are Haematopoietic stem cells?
they are multipotent stem cells that can gove rise to cells of every blood lineage. It is self-maintaining and can divide to produce more stem cells
What are undifferentiated progenitor cells?
No difference between them morphologically because they do not show characteristics of mature cell. They are Multipotent.
What are committed progenitor cells?
already committed as to what they will become when they generate mature cells. They are unipotent
How does Leukaemia arise?
A primary mutation is required in only one of the haematopoietic stem cells .
And then a second mutation is needed in either the mutlipotent progenitors or the common myeloid progenitors or common lymphoid progenitors.
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Describe the symptoms of Leukaemia?
- abnormal bruising
- repeating abnormal infection
- sometimes anaemia
What 3 tests can be used to diagnose Leukaemia?
- peripheral blood blasts test (checks presence of blasts and cytopenia. Higher than 30% blasts are suspected of acute leukaemia)
- bone marrow test/ biopsy (taken from pelvic bone and results are compared with peripheral blood blasts test)
- Lumbar puncture (to determine if the leukaemia has spread to cerebral spinal fluid)
What are some genetic risk factors for Leukaemia?
It is not usually hereditary
- some rare genetic diseases may lead to leukaemia: like Faconi’s anaemia and Down’s syndrome
- gene mutations that invlove oncogenes activation or tumour supressor genes inactivation that are inherited could cause Leukaemia
- Inherited immune system problems
What are some environmental risk factors for Leukaemia?
RADIATION EXPOSURE:
- acute radiation accidents
- atomic bomb survivors
EXPOSURE O CHEMICALS AND CHEMOTHERAPY:
- cancer chemotherapy with alkylating agents
- industrial exposure to benzene
IMMUNE SYSTEM SUPPRESSION:
- after organ transplant
What are some lifestyle related factors linked with Leukaemia?
smoking
drinking
excessive exposure to the sun
overweight
What are some controversial risk factors linked with Leukaemia?
- exposure to electromagnetic fields
- infections in early life
- mother’s age when child is born
- nuclear power stations
- parent smoking history
What are the 4 types of Leukaemia?
Acute Lymphoid Leukaemia
Acute Myeloid Leukaemia
Chronic Lymphoid Leukaemia
Chronic Myeloid Leukaemia
What is meant by acute Leukaemia?
rapid onset an short but severe course
- undiffeentiated leukaemeia
- characterised by uncontrolled accumulation of immature white blood cells (blasts)
What are the characteristics of a patient with acute leukaemia?
- mainly children
- the onset is sudden
- lasts weeks to months
- white blood cell count is variable
What is meant by chronic Leukemia?
persisting over a long time
- differentiated leukaemia
- characterised by accumulation of mature white blood cells (cytes)