L1 - Causes of Disease

Question 1

What is meant by the term ‘Etiology’?

Answer 1

The specific causes of a disease

Question 2

What is meant by the term ‘Pathology’?

Answer 2

The molecular process - causes and effects of a disease

Question 3

What are conditions with no known cause called?

Answer 3

Idiopathic diseases (can be called sporadic)

Question 4

What are the causes of disease classified into and what do they mean?

Answer 4

Intrinsic and Extrinsic disease
Intrinsic diseases come from within the body
Extrinsic diseases come from outside the body

Question 5

Describe some intrinsic causes of disease

Answer 5

CHANGES TO A PERSONS GENOME

• could be nuclear/mitochondrial diseases or inherited mutations
• de novo mutations
• epigenetic modifications

Question 6

What 2 levels can the effects of genetic variations, manifest at and what is the difference?

Answer 6

Cell - autonomously = when a cell is missing something and therefore lacks function or structure
Cell - non autonomously = when a cell is missing something which affects the function of another cell

Question 7

Describe some Extrinsic causes of disease?

Answer 7

• Injury
• Nutrition and diet
• infection
• lifestyle
• chemical poisoning
• exposure to radiation