L2 - Master regulators of Organ System Flashcards
Where is glucose secreted into?
pancreas
two main hormones responsible for maintaining glucose concentrations in the pancreas
insulin and glucagon
Two functional components of pancreas
exocrine component and endocrine component
Exocrine cells
- produce enzymes to help with ingestion of food
- acinar cells and duct cells
Endocrine cells
- consists of Islets of Langerhans (alpha cells, beta cells and delta cells)
Alpha cells
secrete glucagon
Beta cells
secrete insulin
Delta cells
secrete somatostatin
What occurs when there is low blood glucose levels?
low blood glucose levels signals the alpha cells in the pancreas to secrete glucagon which stimulates the liver to breakdown glycogen to glucose to secrete into the blood
What particular enzyme if required for the breakdown of glycogen to glucose?
glucose-6-phosphate
What occurs when there is high blood glucose levels?
high blood glucose levels signals the beta cells in the pancreas to secrete insulin which stimulates the fat cells to take up glucose from the blood causing the glucose levels in the blood cells to reach a normal level
Endocrine glands
- groups of endocrine cells that are dedicated to a given function
- hypothalamus, pituitary and pineal gland
- thyroid gland
- adrenal gland
- pancreas
- ovaries
- testes
Hypothalamus
- small neuroendocrine structure found just above brainstem
- responsible for release of antidiuretic hormone (ADH) and oxytocin, and for the production of regulatory hormones via the pituitary gland
Antidiuretic hormone (ADH)
acts on kidneys to prevent fluid loss or water loss
Oxytcin
involved in the production of milk in females during lactation