L2: Epithelium Flashcards
where is epithelia tissue found
body surfaces
lines hollow organs, cavities and ducts
forms glands of the body
key functions of epithelial tissue
selective barrier
secretory
protective
types of cell junctions
tight
adherens
desmosomes
hemidesmosomes
gap
composition of the cytoskeleton
microfilaments and intermediate filaments
function of microfilaments
strength
alter cell shape
link cytoplasm to membrane
tie cells together
muscle contraction
proteins involved in tight junctions
claudins and occludins
tight junctions are common in the
stomach
intestines
bladder
how do tight junctions maintain cell polarity
preventing migration of proteins between apical and basal surfaces
proteins involved in adherens junctions
cadherins and catenins
plaque layer in adherens junctions links what to what
actin to cadherins
function of adherens junctions
prevent cell separation from tension forces like in contractions
proteins involved in desmosome junctions
cadherins and desmoplakin
desmosome junctions link what to what
link cell surface to keratin
desmosome junctions are common in
skin epithelium and cardiac cells
function of desmosome junctions
resist shearing forces and bind muscle cells
proteins involved in gap junctions
6 connexIns make 1 connexOn
what size molecules do gap junctions allow through
up to 1kDa
function of hemidesmosome
connect epithelia to basement membrane
link keratin to basement membrane
proteins involved in hemidesmosomes
integrin
laminin
keratin
junctional complex
tight + adherens junctions + desmosome
composition of basement membrane
basal and reticular lamina
describe basal lamina
secreted by epithelial cells
contains collagen, laminin, proteoglycans and glycoproteins
describe reticular lamina
produced by fibroblasts in CT
contain fibrous proteins like collagen, fibronectin
function of basment membrane
support overlying epithelia
migratory surface for epithelia cells during growth and wound healing
physical barrier
filtration of substances in kidney