L2: Axon Growth and Target innervatopn Flashcards
1
Q
describe the growth cone shape
A
Fan-shaped sheet with many long thin spikes radiating forward
2
Q
what are lamellipodia
A
“pam” of growth cone (sheet)
3
Q
_____ dynamics are important for growth dynamics
A
cytoskeletal dynamics are important for growth cone dynamics
4
Q
describe axon formation
A
neurons sprouts immature processes called neurites and one matures into an axon, filopodium adheres to adjacent extracellular structures, microtubules advance into the filopodium,
5
Q
name the four types of guidance cues
A
contact repulsion
contact attraction
chemorepulsion
chemoattraction
6
Q
what happens if a growth cone detects a repulsive signal
A
changes in cytoskeletal and membrane domains, turns growth cone
7
Q
what are the major targets for guidance cues
A
microtubules and axons
