(L19) Amyloidosis Flashcards
1
Q
What is the pathophysiology of AA amyloidosis?
L19 S3;11
A
Inflammation triggers the liver to release SAA.
SAA is broken down to AA which can then accumulate.
Protein forms difficult to degrade β sheets and align to form fibrils.
2
Q
What is “apple green” birefringence?
L19 S24
A
It is the color that amyloid makes when stained with Congo Red and looked at with a polarized light filter.
3
Q
What causes amyloidosis?
L19 S40
A
Chronic inflammatory conditions:
- rheumatologic disease
- GI inflammatory diseases
- chronic infections
- hematologic malignancies
- hereditary disorders
