l15 Neurobiology of Dementias and Clinical Aspects

Question 1

what are the domains of cognitive impairment

Answer 1

• memory
• language
• visuospatial function
• social
• executive

Question 2

what is visuospatial function

Answer 2

way-finding hand-eye coordination arranging objects copying a drawing

Question 3

what causes brain dysfunction

Answer 3

hypothyroidism

sodium

drugs

depression

poor sleep

pain

Question 4

what causes brain damage

Answer 4

vascular disease - small vessel cerebrovascular disease-

alcohol

HIV

MS

tumour

B12

Question 5

does vascular disease - small vessel cerebrovascular disease- worsen or cause dementia

Answer 5

Worsen usually

Question 6

what’s a neurodegenerative disease

Answer 6

Alzheimers

Lewy body disease- parkinsons only affecting cognitive function

Question 7

molecular process of Neurodegenerative diseases

Answer 7

Aggregation of misfolding proteins

Question 8

molecular alzheimers disease

Answer 8

Amyloid Beta proteins connections occur extracellularly

Question 9

Causes of alcohol

Answer 9

Wernicke’s
&
Korsakoff’s

Question 10

what does Wernicke’s cause

Answer 10

Delirium
Ataxia
eye movements

Question 11

what does Korsakoff’s cause

Answer 11

amnesia
confabulation
consolidation

Question 12

long term alcoholics

Answer 12

liver disease

seizures

malnutrition