L14-16 drugs

Question 1

Epinephrine

Half life:

MOA:

Elimination:

Indication:

Answer 1

Half life: short
MOA: a and B agonist
Elimination: COMT-urine
Indication: Anaphylaxis, shock, cardiac arrest, and heart block

Question 2

Norepinephrine

Half life:

MOA:

Elimination:

Indication:

Answer 2

Half life: short

MOA: a- agonist, B1- agonist

Elimination: MOA and COMT- urine

Indication: Acute hypotension due to shock

Question 3

Dopamine

Half life:

MOA:

Elimination:

Indication:

Answer 3

Half life: ~2 minutes

MOA: B-agonist, some a- agonist activity

Elimination: MAO and COMT- urine

Indication: Cardiogenic shock

Question 4

Isoproterenol

Half life:

MOA:

Elimination:

Indication:

Answer 4

Half life: Short

MOA: B-agonist (non-selective)

Elimination: COMT- urine

Indication: Transient Heart block

Question 5

Dobutamine

Half life:

MOA:

Elimination:

Indication:

Answer 5

Half life: 2-3 minutes

MOA: B1- agonist

Elimination: COMT- urine (rapid)

Indication: Short term Rx for low cardiac contractility (cardia insufficiency and cadiogenic shock)

Question 6

Terbutaline

MOA:

Indication:

Answer 6

MOA: B2- agonist

Indication: Prevent and reverse bronchospasm in asthma, bronchitis and emphysema

Question 7

Albuterol
MOA:

Indication:

Answer 7

MOA: B2-agonist

Indication: Bronchial SM relaxation

Question 8

Phenylephrine

half-life:

MOA:

Indication:

Answer 8

half-life: less than 1 hr

MAO: A1 agonist

indications: pressor agent for anesthesia, nasal congestion, dilate pupil

Question 9

clonidine

MOA:

Indication:

Answer 9

MOA: a2-agonist

Indication: hypertension

Question 10

Amphetamine

MOA:

Indication:

Answer 10

MOA: Indirect sympathomimetic

Indication: ADHD

Question 11

Methylphenidate

MOA:

Indication:

Answer 11

MOA: indirect sympathomimetic

Indication: ADHD

Question 12

Ephedrine

MOA:

Indication:

Answer 12

MOA: indirect sympathomimetic

Indication: Pressor agent with anesth.

Question 13

Methylphenidate

MOA:

Indication:

Answer 13

MOA: Indirect sympathomimetic

Indication: ADHD

Question 14

pseudo-ephedrine

MOA:

Indication:

Answer 14

MOA: indirect sympathomimetic

Indication: nasal decongestion

Question 15

Tyramine

Half-life:

MOA:

Elimination:

Indication:

Answer 15

half-life: normally very short

MOA: displaces NE

elimination: MAO

Indication: not therapeutic

Question 16

Propranolol

Half-life:

MOA:

Indication:

Answer 16

Half-life: 4 hrs

MOA: B-Blocker

Indication: Hypertension, angina due to atherosclerosis, MI

Question 17

Timolol

Half-life:

MOA:

Indication:

Answer 17

Half-life: 4 hours

MOA: B-blocker

Indication: glaucoma

Question 18

Nadolol

Half-life:

MOA:

Indication:

Answer 18

Half-life: 20-24 hours

MOA: B-blocker

Indication: long-term angina, hypertension

Question 19

Atenolol

MOA:

Indication:

Answer 19

MOA: B1-blocker

Indication: hypertension, angina, MI

Question 20

Metoprolol

MOA:

Indication:

Answer 20

MOA: B1-antagonist

Indication: hypertension, long-term angina rx

Question 21

Pindolol

MOA:

Indication:

Answer 21

MOA: B-antagonist (w/ partial agonist activity)

Indication: hypertension

Question 22

Esmolol

Half-life:

MOA:

Indication:

Answer 22

half-life: ~9 min

MOA: B1-Blocker

Indication: Supra-ventricular tachycardia

Question 23

Pheonxy-benzamine

MOA:

Indication:

Answer 23

MOA: a-blocker

Indication: pheochromo-cytoma

Question 24

Doxazonsin

MOA:

Answer 24

MOA: A1-antagonist

Question 25

Terazosin

MOA:

Indication:

Answer 25

MOA: a1-blocker

Indication: Prostatic hyperplasia, hypertension