L13 PHRM20001 - Pharmacological targets for therapeutic drugs Flashcards
1
Q
To increase the action of an endogenous transmitter
A
- increase synthesis
- inhibit metabolism
- increase release
- inhibit re-uptake or breakdown
- give drug that mimics its action
2
Q
To decrease the action of an endogenous transmitter
A
- inhibit synthesis
- inhibit release
- increase reuptake or breakdown
- give drug that blocks its action
3
Q
What inhibits COX? (2)
A
Non-steroidal anti-inflammatory drugs (NSAIDs) & Glucocorticoids (inhibit COX synthesis)
4
Q
What receptor inhibits release from nerves?
A
Alpha 2
5
Q
PGE2 bad & good effects
A
Bad - hyperalgesic, pyrogenic
Good - vasodilator, increases mucous in gut
6
Q
How to reduce pain? (2)
A
Inhibit COX to reduce PGE2 synthesis.
Activate central opioid receptors.
