L13 Intro Flashcards

1
Q

trophic effect

A

a hormone regulates hormone secretion from another gland
-or-
growth and integrity of the endrocrine gland

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2
Q

pleiotropic effects

A

having several effects

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3
Q

intracrine

A

hormone regulates processes within the cells of orgin WITHOUT BEING SECRETED

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4
Q

neurocrine

A

hormone which originates in neuron, travels down axon, and is carried distally either by a blood vessel or by synaptic transmission

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5
Q

novel endocrine glands

A

epicardial fat of the heart
adipose tissue
skeletal muscle

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6
Q

classic endocrine glands

A
hypothalamus
pituitary
pineal gland
thryoid gland
parathyroid glands
pancreas 
GI tract
placenta
ovaries
testes
thymus
adrenal coretx
adrenal medullae
kidney
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7
Q

hormones derived from a gene which is transcribed into mRNA

A

peptide hormones

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8
Q

hormones derived from tyrosine

A

amine hormones

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9
Q

hormones derived from cholesterol

A

steroid hormones

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10
Q

most hormones are

A

peptide hormones

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11
Q

cholesterol has a

A

cyclopentanoperhydrophenathene ring

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12
Q

peptide hormones that contain a carbohydrate moiety

A

glycoproteins

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13
Q

hydrophilic hormones are dissolved in the bloodstream and include

A

peptide hormones

catecholamines

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14
Q

hydrophobic hormones aka

A

lipophilic hormones

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15
Q

hydrophilic hormones are transported bound to binding proteins and include

A

thryoid hormones

steroid hormones

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16
Q

binding proteins

A
  1. provide hormone reserve
  2. keep hormone inactive
  3. increase hormone half life
  4. are involved in hormone turnover
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17
Q

delivery of hormones to target tissues is regulated by

A

blood flow

18
Q

secretion of hormones is regulated by

A

rate of production

feedback mechanisms

19
Q

metabolism of a hormone in the liver/kidney is dependent on

A

glucuronidation and sulfate conjugation

20
Q

glucuronidation and sulfate conjugation

A

increase solubility of hormones for excretion

21
Q

peptide hormones are stored in

A

granules

22
Q

peptide hormones are synthesized in

A

ribosomes
ER
golgi

23
Q

precursor of catecholamines

A

tyrosine

24
Q

precursor of thyroid hormones

A

tyrosine and iodide

25
Q

catecholamine site of synthesis

A

enzymatic in cytosol

26
Q

T3 T4 sites of synthesisis

A

follicular cell and colloid of thyroid

27
Q

amines are stored in

A

granules

28
Q

T3 and T4 are stored in

A

follicular cells

29
Q

steroids site of synthesis

A

cytosol
ER
mitochondria

30
Q

steroids homrones are stored in

A

NOT STORED

synthesisis and release upon stimulation

31
Q

secretion of polypeptide and protein hormones is stimulated by

A

increased cAMP and Ca++ causing exocytosis of vesicles

32
Q

hormones which may undergo peripharl tissue conversion after being released

A

steroids

amines

33
Q

humoral triggers of hormone secretion

A

activated by a blood borne substrate, whose concentration is either above or below the setpoint

34
Q

low plasma calcium triggers

A

PTH release from parathyroid gland

35
Q

PTH acts to

A

raise blood calcium to normal

36
Q

neural triggers of hormone secretion

A

extension of the CNS that signals glands to secrete hormones

37
Q

hormonal triggers of hormone secretion

A

hormones regulate secretion of hormones

38
Q

threshold

A

the minimum concentration of a hormone required to achieve a response

39
Q

sensitivity

A

the concentration of a hormone which produces 50% of the maximum response

40
Q

maximal response

A

the effect of a saturating dose of a hormone

41
Q

decreased maximal response

A

decreased target cells

decreased signal transduction w/in target cells

42
Q

decreased sensitivity

A

decrease in hormone-receptor affinity

decreased receptor number